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Risk factors for venous thromboembolism and evaluation of the modified Caprini score in patients undergoing lung resection

BACKGROUND: There is a high incidence of venous thromboembolism (VTE) after lung resection, so it is necessary to identify the risk factors for VTE in these patients. It is also important to evaluate whether the modified Caprini score can accurately assess the risk of VTE in patients after lung rese...

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Autores principales: Cui, Songping, Chen, Shuo, Li, Hui, Ke, Lihui, Liu, Yi, Jiang, Ruiheng, Hu, Bin, Li, Tong, Wang, Yang, Miao, Jinbai, Zhang, Wenqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578470/
https://www.ncbi.nlm.nih.gov/pubmed/33145053
http://dx.doi.org/10.21037/jtd-20-1279
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author Cui, Songping
Chen, Shuo
Li, Hui
Ke, Lihui
Liu, Yi
Jiang, Ruiheng
Hu, Bin
Li, Tong
Wang, Yang
Miao, Jinbai
Zhang, Wenqian
author_facet Cui, Songping
Chen, Shuo
Li, Hui
Ke, Lihui
Liu, Yi
Jiang, Ruiheng
Hu, Bin
Li, Tong
Wang, Yang
Miao, Jinbai
Zhang, Wenqian
author_sort Cui, Songping
collection PubMed
description BACKGROUND: There is a high incidence of venous thromboembolism (VTE) after lung resection, so it is necessary to identify the risk factors for VTE in these patients. It is also important to evaluate whether the modified Caprini score can accurately assess the risk of VTE in patients after lung resection. METHODS: This retrospective study included 437 patients undergoing lung resection between July 2016 and December 2017. All patients underwent lower extremities ultrasound before and after operation to determine the presence of the newly diagnosed VTE. RESULTS: Forty-seven (10.8%) of the 437 patients were diagnosed with VTE after lung surgery. Multivariate logistic regression analysis showed that age (OR, 2.04; 95% CI, 1.40–2.99), duration of operation (OR, 1.51; 95% CI, 1.08–2.12), lymphocyte count (OR, 0.28; 95% CI, 0.11–0.69), and D-dimer concentration (OR, 1.55; 95% CI, 1.22–1.97) were significantly associated with VTE in lung resection patients. The cut-off values for lymphocyte count and D-dimer concentration determined using receiver operating characteristic (ROC) curve were 1.15×10(9)/L and 1.37 µg/mL respectively. The modified Caprini score divided the patients into three groups: low risk (0–4 points), moderate risk (5–8 points) and high risk (≥9 points), and the incidence of VTE was 12.3% (37/300), 7.5% (10/133) and 0% (0/4), respectively (P>0.05). CONCLUSIONS: In this study, we identified four independent factors for VTE after lung resection patients: age, duration of operation, lymphocyte count, and D-dimer. According to the modified Caprini score, there were fewer patients in the high-risk group, and the incidence of VTE not increased with the increase of risk. Better evaluation of operation time and D-dimer may help the modified Caprini score to better assess VTE risk in these patients.
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spelling pubmed-75784702020-11-02 Risk factors for venous thromboembolism and evaluation of the modified Caprini score in patients undergoing lung resection Cui, Songping Chen, Shuo Li, Hui Ke, Lihui Liu, Yi Jiang, Ruiheng Hu, Bin Li, Tong Wang, Yang Miao, Jinbai Zhang, Wenqian J Thorac Dis Original Article BACKGROUND: There is a high incidence of venous thromboembolism (VTE) after lung resection, so it is necessary to identify the risk factors for VTE in these patients. It is also important to evaluate whether the modified Caprini score can accurately assess the risk of VTE in patients after lung resection. METHODS: This retrospective study included 437 patients undergoing lung resection between July 2016 and December 2017. All patients underwent lower extremities ultrasound before and after operation to determine the presence of the newly diagnosed VTE. RESULTS: Forty-seven (10.8%) of the 437 patients were diagnosed with VTE after lung surgery. Multivariate logistic regression analysis showed that age (OR, 2.04; 95% CI, 1.40–2.99), duration of operation (OR, 1.51; 95% CI, 1.08–2.12), lymphocyte count (OR, 0.28; 95% CI, 0.11–0.69), and D-dimer concentration (OR, 1.55; 95% CI, 1.22–1.97) were significantly associated with VTE in lung resection patients. The cut-off values for lymphocyte count and D-dimer concentration determined using receiver operating characteristic (ROC) curve were 1.15×10(9)/L and 1.37 µg/mL respectively. The modified Caprini score divided the patients into three groups: low risk (0–4 points), moderate risk (5–8 points) and high risk (≥9 points), and the incidence of VTE was 12.3% (37/300), 7.5% (10/133) and 0% (0/4), respectively (P>0.05). CONCLUSIONS: In this study, we identified four independent factors for VTE after lung resection patients: age, duration of operation, lymphocyte count, and D-dimer. According to the modified Caprini score, there were fewer patients in the high-risk group, and the incidence of VTE not increased with the increase of risk. Better evaluation of operation time and D-dimer may help the modified Caprini score to better assess VTE risk in these patients. AME Publishing Company 2020-09 /pmc/articles/PMC7578470/ /pubmed/33145053 http://dx.doi.org/10.21037/jtd-20-1279 Text en 2020 Journal of Thoracic Disease. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Cui, Songping
Chen, Shuo
Li, Hui
Ke, Lihui
Liu, Yi
Jiang, Ruiheng
Hu, Bin
Li, Tong
Wang, Yang
Miao, Jinbai
Zhang, Wenqian
Risk factors for venous thromboembolism and evaluation of the modified Caprini score in patients undergoing lung resection
title Risk factors for venous thromboembolism and evaluation of the modified Caprini score in patients undergoing lung resection
title_full Risk factors for venous thromboembolism and evaluation of the modified Caprini score in patients undergoing lung resection
title_fullStr Risk factors for venous thromboembolism and evaluation of the modified Caprini score in patients undergoing lung resection
title_full_unstemmed Risk factors for venous thromboembolism and evaluation of the modified Caprini score in patients undergoing lung resection
title_short Risk factors for venous thromboembolism and evaluation of the modified Caprini score in patients undergoing lung resection
title_sort risk factors for venous thromboembolism and evaluation of the modified caprini score in patients undergoing lung resection
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578470/
https://www.ncbi.nlm.nih.gov/pubmed/33145053
http://dx.doi.org/10.21037/jtd-20-1279
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