Microsatellite Instability-high Intrahepatic Cholangiocarcinoma with Portal Vein Tumor Thrombosis Successfully Treated with Pembrolizumab

A 60-year-old man presented with postoperative recurrence of intrahepatic cholangiocarcinoma with right portal vein tumor thrombosis (PVTT). After failure of standard chemotherapy, a liver biopsy showed that his microsatellite instability (MSI) status was high. Treatment with the immune checkpoint i...

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Detalles Bibliográficos
Autores principales: Naganuma, Atsushi, Sakuda, Takayoshi, Murakami, Tatsuma, Aihara, Kosuke, Watanuki, Yuta, Suzuki, Yuhei, Shibasaki, Erina, Masuda, Tomoyuki, Uehara, Sanae, Yasuoka, Hidetoshi, Hoshino, Takashi, Kudo, Tomohiro, Ishihara, Hiroshi, Ogawa, Tetsushi, Kitamoto, Yoshizumi, Ogawa, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578609/
https://www.ncbi.nlm.nih.gov/pubmed/32536644
http://dx.doi.org/10.2169/internalmedicine.4588-20
Descripción
Sumario:A 60-year-old man presented with postoperative recurrence of intrahepatic cholangiocarcinoma with right portal vein tumor thrombosis (PVTT). After failure of standard chemotherapy, a liver biopsy showed that his microsatellite instability (MSI) status was high. Treatment with the immune checkpoint inhibitor (ICI) pembrolizumab was commenced, which resulted in a partial response and resolution of the PVTT. There were no significant immune-related adverse events. According to recently published reports, the frequency of MSI-high biliary tract cancer (BTC) is about 0-2.1%, which is extremely rare. However, ICIs may be effective in patients with MSI-high BTC, such as the present patient.

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