The OGTT is highly reproducible in Africans for the diagnosis of diabetes: Implications for treatment and protocol design

Whether an OGTT reproducibly detects either type 2 diabetes (T2D) or prediabetes in Africans in unknown. Therefore, 131 Africans had two OGTT. Diagnostic reproducibility for T2D was excellent (κ = 0.84), but only moderate for prediabetes (κ = 0.51). A single OGTT positive for T2D may be sufficient t...

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Autores principales: Jagannathan, Ram, DuBose, Christopher W., Mabundo, Lilian S., Chung, Stephanie T., Ha, Joon, Sherman, Arthur, Bergman, Michael, Sumner, Anne E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578647/
https://www.ncbi.nlm.nih.gov/pubmed/33153960
http://dx.doi.org/10.1016/j.diabres.2020.108523
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author Jagannathan, Ram
DuBose, Christopher W.
Mabundo, Lilian S.
Chung, Stephanie T.
Ha, Joon
Sherman, Arthur
Bergman, Michael
Sumner, Anne E.
author_facet Jagannathan, Ram
DuBose, Christopher W.
Mabundo, Lilian S.
Chung, Stephanie T.
Ha, Joon
Sherman, Arthur
Bergman, Michael
Sumner, Anne E.
author_sort Jagannathan, Ram
collection PubMed
description Whether an OGTT reproducibly detects either type 2 diabetes (T2D) or prediabetes in Africans in unknown. Therefore, 131 Africans had two OGTT. Diagnostic reproducibility for T2D was excellent (κ = 0.84), but only moderate for prediabetes (κ = 0.51). A single OGTT positive for T2D may be sufficient to guide clinical care and inform epidemiologic study design. ClinicalTrials.gov Identifier: NCT00001853.
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spelling pubmed-75786472020-10-22 The OGTT is highly reproducible in Africans for the diagnosis of diabetes: Implications for treatment and protocol design Jagannathan, Ram DuBose, Christopher W. Mabundo, Lilian S. Chung, Stephanie T. Ha, Joon Sherman, Arthur Bergman, Michael Sumner, Anne E. Diabetes Res Clin Pract Brief Report Whether an OGTT reproducibly detects either type 2 diabetes (T2D) or prediabetes in Africans in unknown. Therefore, 131 Africans had two OGTT. Diagnostic reproducibility for T2D was excellent (κ = 0.84), but only moderate for prediabetes (κ = 0.51). A single OGTT positive for T2D may be sufficient to guide clinical care and inform epidemiologic study design. ClinicalTrials.gov Identifier: NCT00001853. Elsevier B.V. 2020-12 2020-10-22 /pmc/articles/PMC7578647/ /pubmed/33153960 http://dx.doi.org/10.1016/j.diabres.2020.108523 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Brief Report
Jagannathan, Ram
DuBose, Christopher W.
Mabundo, Lilian S.
Chung, Stephanie T.
Ha, Joon
Sherman, Arthur
Bergman, Michael
Sumner, Anne E.
The OGTT is highly reproducible in Africans for the diagnosis of diabetes: Implications for treatment and protocol design
title The OGTT is highly reproducible in Africans for the diagnosis of diabetes: Implications for treatment and protocol design
title_full The OGTT is highly reproducible in Africans for the diagnosis of diabetes: Implications for treatment and protocol design
title_fullStr The OGTT is highly reproducible in Africans for the diagnosis of diabetes: Implications for treatment and protocol design
title_full_unstemmed The OGTT is highly reproducible in Africans for the diagnosis of diabetes: Implications for treatment and protocol design
title_short The OGTT is highly reproducible in Africans for the diagnosis of diabetes: Implications for treatment and protocol design
title_sort ogtt is highly reproducible in africans for the diagnosis of diabetes: implications for treatment and protocol design
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578647/
https://www.ncbi.nlm.nih.gov/pubmed/33153960
http://dx.doi.org/10.1016/j.diabres.2020.108523
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