TGF-β1 is a regulator of the pyruvate dehydrogenase complex in fibroblasts

TGF-β1 reprograms metabolism in renal fibroblasts, inducing a switch from oxidative phosphorylation to aerobic glycolysis. However, molecular events underpinning this are unknown. Here we identify that TGF-β1 downregulates acetyl-CoA biosynthesis via regulation of the pyruvate dehydrogenase complex...

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Detalles Bibliográficos
Autores principales: Smith, Edward R., Hewitson, Timothy D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578649/
https://www.ncbi.nlm.nih.gov/pubmed/33087819
http://dx.doi.org/10.1038/s41598-020-74919-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578649/
https://www.ncbi.nlm.nih.gov/pubmed/33087819
http://dx.doi.org/10.1038/s41598-020-74919-8

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