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TGF-β1 is a regulator of the pyruvate dehydrogenase complex in fibroblasts

TGF-β1 reprograms metabolism in renal fibroblasts, inducing a switch from oxidative phosphorylation to aerobic glycolysis. However, molecular events underpinning this are unknown. Here we identify that TGF-β1 downregulates acetyl-CoA biosynthesis via regulation of the pyruvate dehydrogenase complex...

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Detalles Bibliográficos
Autores principales:	Smith, Edward R., Hewitson, Timothy D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578649/ https://www.ncbi.nlm.nih.gov/pubmed/33087819 http://dx.doi.org/10.1038/s41598-020-74919-8

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