Degradation of Mutant Protein Aggregates within the Endoplasmic Reticulum of Vasopressin Neurons

Misfolded or unfolded proteins in the ER are said to be degraded only after translocation or isolation from the ER. Here, we describe a mechanism by which mutant proteins are degraded within the ER. Aggregates of mutant arginine vasopressin (AVP) precursor were confined to ER-associated compartments...

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Detalles Bibliográficos
Autores principales: Miyata, Takashi, Hagiwara, Daisuke, Hodai, Yuichi, Miwata, Tsutomu, Kawaguchi, Yohei, Kurimoto, Junki, Ozaki, Hajime, Mitsumoto, Kazuki, Takagi, Hiroshi, Suga, Hidetaka, Kobayashi, Tomoko, Sugiyama, Mariko, Onoue, Takeshi, Ito, Yoshihiro, Iwama, Shintaro, Banno, Ryoichi, Matsumoto, Mami, Kawakami, Natsuko, Ohno, Nobuhiko, Sakamoto, Hirotaka, Arima, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578753/
https://www.ncbi.nlm.nih.gov/pubmed/33103081
http://dx.doi.org/10.1016/j.isci.2020.101648

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