Cargando…

E3 Ligase FBXW2 Is a New Therapeutic Target in Obesity and Atherosclerosis

Chronic low‐grade inflammation orchestrated by macrophages plays a critical role in metabolic chronic diseases, like obesity and atherosclerosis. However, the underlying mechanism remains to be elucidated. Here, the E3 ubiquitin ligase F‐box/WD Repeat‐Containing Protein 2 (FBXW2), the substrate‐bind...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Cheng, Xu, Wenjing, Chao, Yuelin, Liang, Minglu, Zhang, Fengxiao, Huang, Kai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578860/ https://www.ncbi.nlm.nih.gov/pubmed/33101872 http://dx.doi.org/10.1002/advs.202001800

Ejemplares similares

FBXW7 E3 ubiquitin ligase: degrading, not degrading, or being degraded
por: Lan, Huiyin, et al.
Publicado: (2019)

E3 Ligase FBXW7 Facilitates Mycobacterium Immune Evasion by Modulating TNF-α Expression
por: Song, Jingrui, et al.
Publicado: (2022)

E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses
por: Song, Yinjing, et al.
Publicado: (2017)

Absence of Interferon Regulatory Factor 1 Protects Against Atherosclerosis in Apolipoprotein E-Deficient Mice
por: Du, Meng, et al.
Publicado: (2019)

E3 ligase FBXW7 restricts M2-like tumor-associated macrophage polarization by targeting c-Myc
por: Zhong, Lijia, et al.
Publicado: (2020)

Myelinating Schwann cells ensheath multiple axons in the absence of E3 ligase component Fbxw7
por: Harty, Breanne L., et al.
Publicado: (2019)

The E3 ubiquitin ligase, FBXW5, promotes the migration and invasion of gastric cancer through the dysregulation of the Hippo pathway
por: Yao, Yangyang, et al.
Publicado: (2022)

Both Ubiquitin Ligases FBXW8 and PARK2 Are Sequestrated into Insolubility by ATXN2 PolyQ Expansions, but Only FBXW8 Expression Is Dysregulated
por: Halbach, Melanie Vanessa, et al.
Publicado: (2015)

Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
por: Wang, Cheng, et al.
Publicado: (2019)

Activity‐Based Probes for HECT E3 Ubiquitin Ligases
por: Byrne, Robert, et al.
Publicado: (2017)

Dysfunction of microRNA-32 regulates ubiquitin ligase FBXW7 in multiple myeloma disease
por: Hua, Jingsheng, et al.
Publicado: (2016)

The SCF–FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage
por: Hänle-Kreidler, Simon, et al.
Publicado: (2022)

Overexpression of microRNA-223 regulates the ubiquitin ligase FBXW7 in oesophageal squamous cell carcinoma
por: Kurashige, J, et al.
Publicado: (2012)

MYC is a critical target of FBXW7
por: Sato, Mai, et al.
Publicado: (2014)

The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor
por: Franz, Joseph, et al.
Publicado: (2015)

Expression levels of FBXW7 and MDM2 E3 ubiquitin ligases and their c-Myc and p53 substrates in patients with dysplastic nevi or melanoma
por: Mozuraitiene, Julija, et al.
Publicado: (2021)

Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity
por: Geeraerts, Xenia, et al.
Publicado: (2017)

Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL
por: Rodriguez, Sonia, et al.
Publicado: (2019)

FBXW7 in breast cancer: mechanism of action and therapeutic potential
por: Chen, Siyu, et al.
Publicado: (2023)

An OBSL1-Cul7(Fbxw8) Ubiquitin Ligase Signaling Mechanism Regulates Golgi Morphology and Dendrite Patterning
por: Litterman, Nadia, et al.
Publicado: (2011)

FBXW7 and human tumors: mechanisms of drug resistance and potential therapeutic strategies
por: Wang, Wanqing, et al.
Publicado: (2023)

The E3 Ubiquitin Ligase Peli1 Deficiency Promotes Atherosclerosis Progression
por: Burger, Fabienne, et al.
Publicado: (2022)

New Insight in HDACs: Potential Therapeutic Targets for the Treatment of Atherosclerosis
por: Luan, Yi, et al.
Publicado: (2022)

Comprehensive Analysis of the Rice RING E3 Ligase Family Reveals Their Functional Diversity in Response to Abiotic stress
por: Lim, Sung Don, et al.
Publicado: (2013)

E3 Ubiquitin Ligases: Potential Therapeutic Targets for Skeletal Pathology and Degeneration
por: Zeng, Ruiyin, et al.
Publicado: (2022)

Implications of FBXW7 in Neurodevelopment and Neurodegeneration: Molecular Mechanisms and Therapeutic Potential
por: Yang, Yu, et al.
Publicado: (2021)

Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p/FBXW7 axis
por: Chen, Xin, et al.
Publicado: (2020)

The promotional effect of microRNA-103a-3p in cervical cancer cells by regulating the ubiquitin ligase FBXW7 function
por: Ren, Li, et al.
Publicado: (2022)

Targeting E3 ubiquitin ligases and their adaptors as a therapeutic strategy for metabolic diseases
por: Jeong, Yelin, et al.
Publicado: (2023)

miR-25 Promotes Cardiomyocyte Proliferation by Targeting FBXW7
por: Wang, Bei, et al.
Publicado: (2020)

SCF(Fbxw5) targets kinesin‐13 proteins to facilitate ciliogenesis
por: Schweiggert, Jörg, et al.
Publicado: (2021)

Camellia oil (Camellia oleifera Abel.) treatment improves high-fat diet-induced atherosclerosis in apolipoprotein E (ApoE)(−/−) mice
por: HUANG, Tianyang, et al.
Publicado: (2022)

The Role of FBXW7 in Gynecologic Malignancies
por: Di Fiore, Riccardo, et al.
Publicado: (2023)

Targeting the Opening of Mitochondrial Permeability Transition Pores Potentiates Nanoparticle Drug Delivery and Mitigates Cancer Metastasis
por: Lin, Xi, et al.
Publicado: (2020)

CRL4(CRBN) E3 Ligase Complex as a Therapeutic Target in Multiple Myeloma
por: Barankiewicz, Joanna, et al.
Publicado: (2022)

25-Hydroxycholesterol protects against myocardial ischemia-reperfusion injury via inhibiting PARP activity
por: Lv, Suying, et al.
Publicado: (2020)

Structural and functional characterization of hMEX‐3C Ring finger domain as an E3 ubiquitin ligase
por: Moududee, Sayed Ala, et al.
Publicado: (2018)

Therapeutic Targeting of MZF1‐AS1/PARP1/E2F1 Axis Inhibits Proline Synthesis and Neuroblastoma Progression
por: Fang, Erhu, et al.
Publicado: (2019)

The E3 ubiquitin ligase seven in absentia homolog 1 may be a potential new therapeutic target for Parkinson's disease
por: Cai, Zeng-lin, et al.
Publicado: (2015)

The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis
por: Ren, Hui, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_u9amcl7572co97gfhctfri4tjk