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Evidence for the existence of CD34(+) angiogenic stem cells in human first‐trimester decidua and their therapeutic for ischaemic heart disease
Stem cell transplantation is nearly available for clinical application in the treatment of ischaemic heart disease (IHD), where it may be joined traditional methods (intervention and surgery). The angiogenic ability of seed cells is essential for this applicability. The aim of this study was to reve...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578869/ https://www.ncbi.nlm.nih.gov/pubmed/32896985 http://dx.doi.org/10.1111/jcmm.15800 |
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author | Bai, Long Sun, Lu Chen, Wei Liu, Kai‐Yu Zhang, Chun‐Feng Wang, Fei Zhang, Gui‐Huan Huang, Ye Li, Jing‐Xuan Gao, Ying Sun, Xin Liu, Wei Du, Guo‐Qing Li, Ren‐Ke Huang, Ming‐Li Tian, Hai |
author_facet | Bai, Long Sun, Lu Chen, Wei Liu, Kai‐Yu Zhang, Chun‐Feng Wang, Fei Zhang, Gui‐Huan Huang, Ye Li, Jing‐Xuan Gao, Ying Sun, Xin Liu, Wei Du, Guo‐Qing Li, Ren‐Ke Huang, Ming‐Li Tian, Hai |
author_sort | Bai, Long |
collection | PubMed |
description | Stem cell transplantation is nearly available for clinical application in the treatment of ischaemic heart disease (IHD), where it may be joined traditional methods (intervention and surgery). The angiogenic ability of seed cells is essential for this applicability. The aim of this study was to reveal the presence of CD34(+) angiogenic stem cells in human decidua at the first trimester and to use their strong angiogenic capacity in the treatment of IHD. In vitro, human decidual CD34(+) (dCD34(+)) cells from the first trimester have strong proliferation and clonality abilities. After ruling out the possibility that they were vascular endothelial cells and mesenchymal stem cells (MSCs), dCD34(+) cells were found to be able to form tube structures after differentiation. Their angiogenic capacity was obviously superior to that of bone marrow mesenchymal stem cells (BMSCs). At the same time, these cells had immunogenicity similar to that of BMSCs. Following induction of myocardial infarction (MI) in adult rats, infarct size decreased and cardiac function was significantly enhanced after dCD34(+) cell transplantation. The survival rate of cells increased, and more neovasculature was found following dCD34(+) cell transplantation. Therefore, this study confirms the existence of CD34(+) stem cells with strong angiogenic ability in human decidua from the first trimester, which can provide a new option for cell‐based therapies for ischaemic diseases, especially IHD. |
format | Online Article Text |
id | pubmed-7578869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75788692020-10-23 Evidence for the existence of CD34(+) angiogenic stem cells in human first‐trimester decidua and their therapeutic for ischaemic heart disease Bai, Long Sun, Lu Chen, Wei Liu, Kai‐Yu Zhang, Chun‐Feng Wang, Fei Zhang, Gui‐Huan Huang, Ye Li, Jing‐Xuan Gao, Ying Sun, Xin Liu, Wei Du, Guo‐Qing Li, Ren‐Ke Huang, Ming‐Li Tian, Hai J Cell Mol Med Original Articles Stem cell transplantation is nearly available for clinical application in the treatment of ischaemic heart disease (IHD), where it may be joined traditional methods (intervention and surgery). The angiogenic ability of seed cells is essential for this applicability. The aim of this study was to reveal the presence of CD34(+) angiogenic stem cells in human decidua at the first trimester and to use their strong angiogenic capacity in the treatment of IHD. In vitro, human decidual CD34(+) (dCD34(+)) cells from the first trimester have strong proliferation and clonality abilities. After ruling out the possibility that they were vascular endothelial cells and mesenchymal stem cells (MSCs), dCD34(+) cells were found to be able to form tube structures after differentiation. Their angiogenic capacity was obviously superior to that of bone marrow mesenchymal stem cells (BMSCs). At the same time, these cells had immunogenicity similar to that of BMSCs. Following induction of myocardial infarction (MI) in adult rats, infarct size decreased and cardiac function was significantly enhanced after dCD34(+) cell transplantation. The survival rate of cells increased, and more neovasculature was found following dCD34(+) cell transplantation. Therefore, this study confirms the existence of CD34(+) stem cells with strong angiogenic ability in human decidua from the first trimester, which can provide a new option for cell‐based therapies for ischaemic diseases, especially IHD. John Wiley and Sons Inc. 2020-09-08 2020-10 /pmc/articles/PMC7578869/ /pubmed/32896985 http://dx.doi.org/10.1111/jcmm.15800 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Bai, Long Sun, Lu Chen, Wei Liu, Kai‐Yu Zhang, Chun‐Feng Wang, Fei Zhang, Gui‐Huan Huang, Ye Li, Jing‐Xuan Gao, Ying Sun, Xin Liu, Wei Du, Guo‐Qing Li, Ren‐Ke Huang, Ming‐Li Tian, Hai Evidence for the existence of CD34(+) angiogenic stem cells in human first‐trimester decidua and their therapeutic for ischaemic heart disease |
title | Evidence for the existence of CD34(+) angiogenic stem cells in human first‐trimester decidua and their therapeutic for ischaemic heart disease |
title_full | Evidence for the existence of CD34(+) angiogenic stem cells in human first‐trimester decidua and their therapeutic for ischaemic heart disease |
title_fullStr | Evidence for the existence of CD34(+) angiogenic stem cells in human first‐trimester decidua and their therapeutic for ischaemic heart disease |
title_full_unstemmed | Evidence for the existence of CD34(+) angiogenic stem cells in human first‐trimester decidua and their therapeutic for ischaemic heart disease |
title_short | Evidence for the existence of CD34(+) angiogenic stem cells in human first‐trimester decidua and their therapeutic for ischaemic heart disease |
title_sort | evidence for the existence of cd34(+) angiogenic stem cells in human first‐trimester decidua and their therapeutic for ischaemic heart disease |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578869/ https://www.ncbi.nlm.nih.gov/pubmed/32896985 http://dx.doi.org/10.1111/jcmm.15800 |
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