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Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk

Magnetic molecularly imprinted polymers (MMIPs) are an invaluable asset in the development of many methods in analytical chemistry, particularly sample preparation. Novel adsorbents based on MMIPs are characterized by high selectivity towards a specific analyte due to the presence of a specific cavi...

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Autores principales: Pajewska-Szmyt, Martyna, Biniewska, Ewelina, Buszewski, Bogusław, Gadzała-Kopciuch, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579064/
https://www.ncbi.nlm.nih.gov/pubmed/33003301
http://dx.doi.org/10.3390/ma13194328
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author Pajewska-Szmyt, Martyna
Biniewska, Ewelina
Buszewski, Bogusław
Gadzała-Kopciuch, Renata
author_facet Pajewska-Szmyt, Martyna
Biniewska, Ewelina
Buszewski, Bogusław
Gadzała-Kopciuch, Renata
author_sort Pajewska-Szmyt, Martyna
collection PubMed
description Magnetic molecularly imprinted polymers (MMIPs) are an invaluable asset in the development of many methods in analytical chemistry, particularly sample preparation. Novel adsorbents based on MMIPs are characterized by high selectivity towards a specific analyte due to the presence of a specific cavity on their polymer surface, enabling the lock–key model interactions to occur. In addition, the magnetic core provides superparamagnetic properties that allow rapid separation of the sorbent from the sample solution. Such a combination of imprinted polymers with a magnetic core has an innovative influence on the development of separation techniques. Hence, the present study describes the synthesis of MMIPs with 17β-estradiol used as a template molecule in the production of imprinted polymers. The as-prepared sorbent was used for a sorption/desorption study of five parabens from breast milk samples. The obtained results were characterized by sorption efficiency exceeding 92%, which shows the high affinity of the analytes to the functional groups on the sorbent. The final determination of the selected analytes was done with high-performance liquid chromatography using a fluorometric detector. The determined linearity ranges for selected parabens were characterized by high determination coefficients (r(2) from 0.9992 to 0.9999), and the calculated limit of detection (LOD) and limit of quantification (LOQ) for the identified compounds were low (LOD from 1.1–2.7 ng mL(−1); LOQ from 3.6–8.1 ng mL(−1)), which makes their quantitative analysis in real samples feasible.
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spelling pubmed-75790642020-10-29 Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk Pajewska-Szmyt, Martyna Biniewska, Ewelina Buszewski, Bogusław Gadzała-Kopciuch, Renata Materials (Basel) Article Magnetic molecularly imprinted polymers (MMIPs) are an invaluable asset in the development of many methods in analytical chemistry, particularly sample preparation. Novel adsorbents based on MMIPs are characterized by high selectivity towards a specific analyte due to the presence of a specific cavity on their polymer surface, enabling the lock–key model interactions to occur. In addition, the magnetic core provides superparamagnetic properties that allow rapid separation of the sorbent from the sample solution. Such a combination of imprinted polymers with a magnetic core has an innovative influence on the development of separation techniques. Hence, the present study describes the synthesis of MMIPs with 17β-estradiol used as a template molecule in the production of imprinted polymers. The as-prepared sorbent was used for a sorption/desorption study of five parabens from breast milk samples. The obtained results were characterized by sorption efficiency exceeding 92%, which shows the high affinity of the analytes to the functional groups on the sorbent. The final determination of the selected analytes was done with high-performance liquid chromatography using a fluorometric detector. The determined linearity ranges for selected parabens were characterized by high determination coefficients (r(2) from 0.9992 to 0.9999), and the calculated limit of detection (LOD) and limit of quantification (LOQ) for the identified compounds were low (LOD from 1.1–2.7 ng mL(−1); LOQ from 3.6–8.1 ng mL(−1)), which makes their quantitative analysis in real samples feasible. MDPI 2020-09-29 /pmc/articles/PMC7579064/ /pubmed/33003301 http://dx.doi.org/10.3390/ma13194328 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pajewska-Szmyt, Martyna
Biniewska, Ewelina
Buszewski, Bogusław
Gadzała-Kopciuch, Renata
Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk
title Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk
title_full Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk
title_fullStr Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk
title_full_unstemmed Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk
title_short Synthesis of Magnetic Molecularly Imprinted Polymer Sorbents for Isolation of Parabens from Breast Milk
title_sort synthesis of magnetic molecularly imprinted polymer sorbents for isolation of parabens from breast milk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579064/
https://www.ncbi.nlm.nih.gov/pubmed/33003301
http://dx.doi.org/10.3390/ma13194328
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