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Gestational Pesticide Exposure and Child Respiratory Health

Background: Childhood wheeze may be related to pesticide exposure, and diet and genetics (Paroxonase; PON1) may modify the effects of exposure. Methods: We analyzed data from the HOME Study, a prospective pregnancy and birth cohort, to examine the association of gestational urinary organophosphate (...

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Autores principales: Gilden, Robyn, Friedmann, Erika, Holmes, Katie, Yolton, Kimberly, Xu, Yingying, Lanphear, Bruce, Chen, Aimin, Braun, Joseph, Spanier, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579149/
https://www.ncbi.nlm.nih.gov/pubmed/33007939
http://dx.doi.org/10.3390/ijerph17197165
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author Gilden, Robyn
Friedmann, Erika
Holmes, Katie
Yolton, Kimberly
Xu, Yingying
Lanphear, Bruce
Chen, Aimin
Braun, Joseph
Spanier, Adam
author_facet Gilden, Robyn
Friedmann, Erika
Holmes, Katie
Yolton, Kimberly
Xu, Yingying
Lanphear, Bruce
Chen, Aimin
Braun, Joseph
Spanier, Adam
author_sort Gilden, Robyn
collection PubMed
description Background: Childhood wheeze may be related to pesticide exposure, and diet and genetics (Paroxonase; PON1) may modify the effects of exposure. Methods: We analyzed data from the HOME Study, a prospective pregnancy and birth cohort, to examine the association of gestational urinary organophosphate (OP) and pyrethroid (3PBA) metabolite concentrations with child wheeze, forced expiratory volume in one second (FEV1) at ages 4 and 5 years, and wheeze trajectory patterns through age 8 years. Results: Among 367 singletons, the frequency of wheeze ranged from 10.6% to 24.1% at each measurement age. OP and 3PBA metabolite concentrations were not associated with wheeze at 8 years or from birth to 8 years, but there were three significant interactions: (1) maternal daily fruit and vegetable consumption (less than daily consumption and increasing 3PBA was associated with wheeze at age 8 years, OR = 1.40), (2) maternal PON1(-108) allele (CT/TT genotypes and high DE was associated with wheeze at age 8 years, OR = 2.13, 2.74) and (3) PON1(192) alleles (QR/RR genotypes with higher diethylphosphate (DE) and dialkyl phosphate (DAP) were associated with wheeze at age 8 years, OR = 3.84). Pesticide metabolites were not consistently related to FEV1 or wheeze trajectory. Conclusions: Gestational OP and 3PBA metabolites were associated with child respiratory outcomes in participants with maternal dietary and genetic susceptibility.
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spelling pubmed-75791492020-10-29 Gestational Pesticide Exposure and Child Respiratory Health Gilden, Robyn Friedmann, Erika Holmes, Katie Yolton, Kimberly Xu, Yingying Lanphear, Bruce Chen, Aimin Braun, Joseph Spanier, Adam Int J Environ Res Public Health Article Background: Childhood wheeze may be related to pesticide exposure, and diet and genetics (Paroxonase; PON1) may modify the effects of exposure. Methods: We analyzed data from the HOME Study, a prospective pregnancy and birth cohort, to examine the association of gestational urinary organophosphate (OP) and pyrethroid (3PBA) metabolite concentrations with child wheeze, forced expiratory volume in one second (FEV1) at ages 4 and 5 years, and wheeze trajectory patterns through age 8 years. Results: Among 367 singletons, the frequency of wheeze ranged from 10.6% to 24.1% at each measurement age. OP and 3PBA metabolite concentrations were not associated with wheeze at 8 years or from birth to 8 years, but there were three significant interactions: (1) maternal daily fruit and vegetable consumption (less than daily consumption and increasing 3PBA was associated with wheeze at age 8 years, OR = 1.40), (2) maternal PON1(-108) allele (CT/TT genotypes and high DE was associated with wheeze at age 8 years, OR = 2.13, 2.74) and (3) PON1(192) alleles (QR/RR genotypes with higher diethylphosphate (DE) and dialkyl phosphate (DAP) were associated with wheeze at age 8 years, OR = 3.84). Pesticide metabolites were not consistently related to FEV1 or wheeze trajectory. Conclusions: Gestational OP and 3PBA metabolites were associated with child respiratory outcomes in participants with maternal dietary and genetic susceptibility. MDPI 2020-09-30 2020-10 /pmc/articles/PMC7579149/ /pubmed/33007939 http://dx.doi.org/10.3390/ijerph17197165 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gilden, Robyn
Friedmann, Erika
Holmes, Katie
Yolton, Kimberly
Xu, Yingying
Lanphear, Bruce
Chen, Aimin
Braun, Joseph
Spanier, Adam
Gestational Pesticide Exposure and Child Respiratory Health
title Gestational Pesticide Exposure and Child Respiratory Health
title_full Gestational Pesticide Exposure and Child Respiratory Health
title_fullStr Gestational Pesticide Exposure and Child Respiratory Health
title_full_unstemmed Gestational Pesticide Exposure and Child Respiratory Health
title_short Gestational Pesticide Exposure and Child Respiratory Health
title_sort gestational pesticide exposure and child respiratory health
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579149/
https://www.ncbi.nlm.nih.gov/pubmed/33007939
http://dx.doi.org/10.3390/ijerph17197165
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