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Correlation between Oral Glucose Tolerance Test Abnormalities and Adverse Pregnancy Outcomes in Gestational Diabetes: A Cross-Sectional Study
Gestational diabetes mellitus (GDM) is associated with maternal and neonatal complications. We aimed to evaluate the relationship between the abnormalities of the oral glucose tolerance test (OGTT) and adverse pregnancy outcomes. This was a retrospective study of GDM patients over a five-year period...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579185/ https://www.ncbi.nlm.nih.gov/pubmed/32987806 http://dx.doi.org/10.3390/ijerph17196990 |
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author | Kalok, Aida Ong, Ming Yean Hasrori, Aqilah Chiang, Ker Shing Yazim, Fatin Baharuddin, Salahuddin Rahman, Rahana Abdul Shah, Shamsul Azhar Aziz, Nor Haslinda Abd Ahmad, Shuhaila Ismail, Nor Azlin Mohamed |
author_facet | Kalok, Aida Ong, Ming Yean Hasrori, Aqilah Chiang, Ker Shing Yazim, Fatin Baharuddin, Salahuddin Rahman, Rahana Abdul Shah, Shamsul Azhar Aziz, Nor Haslinda Abd Ahmad, Shuhaila Ismail, Nor Azlin Mohamed |
author_sort | Kalok, Aida |
collection | PubMed |
description | Gestational diabetes mellitus (GDM) is associated with maternal and neonatal complications. We aimed to evaluate the relationship between the abnormalities of the oral glucose tolerance test (OGTT) and adverse pregnancy outcomes. This was a retrospective study of GDM patients over a five-year period in a Malaysian tertiary center. The diagnosis of GDM was based on the National Institute for Health and Care Excellence (NICE) guideline. The data on patients’ demographics, OGTT results, GDM treatment, and pregnancy outcomes were analyzed. A total of 1105 women were included in the final analysis. The percentage of women with isolated abnormal fasting glucose, isolated two-hour abnormality, and both abnormal values were 4.8%, 87.1%, and 8.1%, respectively. Women with both OGTT abnormalities had a higher risk of preeclampsia (odds ratio (OR) 4.73; 95% confidence interval (CI) 1.45–15.41) and neonatal hypoglycemia (OR 8.78; 95% CI 1.93–39.88). Isolated postprandial abnormality was associated with an 80% lesser risk of neonatal hypoglycemia (OR 0.19; 95% CI 0.04–0.87). Both isolated fasting and multiple OGTT abnormalities were associated with insulin therapy. Multiple OGTT abnormalities were a positive predictor of adverse pregnancy outcomes, while isolated postprandial abnormality was associated with a lesser risk of neonatal complication. Further prospective study is essential to validate these findings. |
format | Online Article Text |
id | pubmed-7579185 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75791852020-10-29 Correlation between Oral Glucose Tolerance Test Abnormalities and Adverse Pregnancy Outcomes in Gestational Diabetes: A Cross-Sectional Study Kalok, Aida Ong, Ming Yean Hasrori, Aqilah Chiang, Ker Shing Yazim, Fatin Baharuddin, Salahuddin Rahman, Rahana Abdul Shah, Shamsul Azhar Aziz, Nor Haslinda Abd Ahmad, Shuhaila Ismail, Nor Azlin Mohamed Int J Environ Res Public Health Article Gestational diabetes mellitus (GDM) is associated with maternal and neonatal complications. We aimed to evaluate the relationship between the abnormalities of the oral glucose tolerance test (OGTT) and adverse pregnancy outcomes. This was a retrospective study of GDM patients over a five-year period in a Malaysian tertiary center. The diagnosis of GDM was based on the National Institute for Health and Care Excellence (NICE) guideline. The data on patients’ demographics, OGTT results, GDM treatment, and pregnancy outcomes were analyzed. A total of 1105 women were included in the final analysis. The percentage of women with isolated abnormal fasting glucose, isolated two-hour abnormality, and both abnormal values were 4.8%, 87.1%, and 8.1%, respectively. Women with both OGTT abnormalities had a higher risk of preeclampsia (odds ratio (OR) 4.73; 95% confidence interval (CI) 1.45–15.41) and neonatal hypoglycemia (OR 8.78; 95% CI 1.93–39.88). Isolated postprandial abnormality was associated with an 80% lesser risk of neonatal hypoglycemia (OR 0.19; 95% CI 0.04–0.87). Both isolated fasting and multiple OGTT abnormalities were associated with insulin therapy. Multiple OGTT abnormalities were a positive predictor of adverse pregnancy outcomes, while isolated postprandial abnormality was associated with a lesser risk of neonatal complication. Further prospective study is essential to validate these findings. MDPI 2020-09-24 2020-10 /pmc/articles/PMC7579185/ /pubmed/32987806 http://dx.doi.org/10.3390/ijerph17196990 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kalok, Aida Ong, Ming Yean Hasrori, Aqilah Chiang, Ker Shing Yazim, Fatin Baharuddin, Salahuddin Rahman, Rahana Abdul Shah, Shamsul Azhar Aziz, Nor Haslinda Abd Ahmad, Shuhaila Ismail, Nor Azlin Mohamed Correlation between Oral Glucose Tolerance Test Abnormalities and Adverse Pregnancy Outcomes in Gestational Diabetes: A Cross-Sectional Study |
title | Correlation between Oral Glucose Tolerance Test Abnormalities and Adverse Pregnancy Outcomes in Gestational Diabetes: A Cross-Sectional Study |
title_full | Correlation between Oral Glucose Tolerance Test Abnormalities and Adverse Pregnancy Outcomes in Gestational Diabetes: A Cross-Sectional Study |
title_fullStr | Correlation between Oral Glucose Tolerance Test Abnormalities and Adverse Pregnancy Outcomes in Gestational Diabetes: A Cross-Sectional Study |
title_full_unstemmed | Correlation between Oral Glucose Tolerance Test Abnormalities and Adverse Pregnancy Outcomes in Gestational Diabetes: A Cross-Sectional Study |
title_short | Correlation between Oral Glucose Tolerance Test Abnormalities and Adverse Pregnancy Outcomes in Gestational Diabetes: A Cross-Sectional Study |
title_sort | correlation between oral glucose tolerance test abnormalities and adverse pregnancy outcomes in gestational diabetes: a cross-sectional study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579185/ https://www.ncbi.nlm.nih.gov/pubmed/32987806 http://dx.doi.org/10.3390/ijerph17196990 |
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