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Correlation between Oral Glucose Tolerance Test Abnormalities and Adverse Pregnancy Outcomes in Gestational Diabetes: A Cross-Sectional Study

Gestational diabetes mellitus (GDM) is associated with maternal and neonatal complications. We aimed to evaluate the relationship between the abnormalities of the oral glucose tolerance test (OGTT) and adverse pregnancy outcomes. This was a retrospective study of GDM patients over a five-year period...

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Autores principales: Kalok, Aida, Ong, Ming Yean, Hasrori, Aqilah, Chiang, Ker Shing, Yazim, Fatin, Baharuddin, Salahuddin, Rahman, Rahana Abdul, Shah, Shamsul Azhar, Aziz, Nor Haslinda Abd, Ahmad, Shuhaila, Ismail, Nor Azlin Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579185/
https://www.ncbi.nlm.nih.gov/pubmed/32987806
http://dx.doi.org/10.3390/ijerph17196990
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author Kalok, Aida
Ong, Ming Yean
Hasrori, Aqilah
Chiang, Ker Shing
Yazim, Fatin
Baharuddin, Salahuddin
Rahman, Rahana Abdul
Shah, Shamsul Azhar
Aziz, Nor Haslinda Abd
Ahmad, Shuhaila
Ismail, Nor Azlin Mohamed
author_facet Kalok, Aida
Ong, Ming Yean
Hasrori, Aqilah
Chiang, Ker Shing
Yazim, Fatin
Baharuddin, Salahuddin
Rahman, Rahana Abdul
Shah, Shamsul Azhar
Aziz, Nor Haslinda Abd
Ahmad, Shuhaila
Ismail, Nor Azlin Mohamed
author_sort Kalok, Aida
collection PubMed
description Gestational diabetes mellitus (GDM) is associated with maternal and neonatal complications. We aimed to evaluate the relationship between the abnormalities of the oral glucose tolerance test (OGTT) and adverse pregnancy outcomes. This was a retrospective study of GDM patients over a five-year period in a Malaysian tertiary center. The diagnosis of GDM was based on the National Institute for Health and Care Excellence (NICE) guideline. The data on patients’ demographics, OGTT results, GDM treatment, and pregnancy outcomes were analyzed. A total of 1105 women were included in the final analysis. The percentage of women with isolated abnormal fasting glucose, isolated two-hour abnormality, and both abnormal values were 4.8%, 87.1%, and 8.1%, respectively. Women with both OGTT abnormalities had a higher risk of preeclampsia (odds ratio (OR) 4.73; 95% confidence interval (CI) 1.45–15.41) and neonatal hypoglycemia (OR 8.78; 95% CI 1.93–39.88). Isolated postprandial abnormality was associated with an 80% lesser risk of neonatal hypoglycemia (OR 0.19; 95% CI 0.04–0.87). Both isolated fasting and multiple OGTT abnormalities were associated with insulin therapy. Multiple OGTT abnormalities were a positive predictor of adverse pregnancy outcomes, while isolated postprandial abnormality was associated with a lesser risk of neonatal complication. Further prospective study is essential to validate these findings.
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spelling pubmed-75791852020-10-29 Correlation between Oral Glucose Tolerance Test Abnormalities and Adverse Pregnancy Outcomes in Gestational Diabetes: A Cross-Sectional Study Kalok, Aida Ong, Ming Yean Hasrori, Aqilah Chiang, Ker Shing Yazim, Fatin Baharuddin, Salahuddin Rahman, Rahana Abdul Shah, Shamsul Azhar Aziz, Nor Haslinda Abd Ahmad, Shuhaila Ismail, Nor Azlin Mohamed Int J Environ Res Public Health Article Gestational diabetes mellitus (GDM) is associated with maternal and neonatal complications. We aimed to evaluate the relationship between the abnormalities of the oral glucose tolerance test (OGTT) and adverse pregnancy outcomes. This was a retrospective study of GDM patients over a five-year period in a Malaysian tertiary center. The diagnosis of GDM was based on the National Institute for Health and Care Excellence (NICE) guideline. The data on patients’ demographics, OGTT results, GDM treatment, and pregnancy outcomes were analyzed. A total of 1105 women were included in the final analysis. The percentage of women with isolated abnormal fasting glucose, isolated two-hour abnormality, and both abnormal values were 4.8%, 87.1%, and 8.1%, respectively. Women with both OGTT abnormalities had a higher risk of preeclampsia (odds ratio (OR) 4.73; 95% confidence interval (CI) 1.45–15.41) and neonatal hypoglycemia (OR 8.78; 95% CI 1.93–39.88). Isolated postprandial abnormality was associated with an 80% lesser risk of neonatal hypoglycemia (OR 0.19; 95% CI 0.04–0.87). Both isolated fasting and multiple OGTT abnormalities were associated with insulin therapy. Multiple OGTT abnormalities were a positive predictor of adverse pregnancy outcomes, while isolated postprandial abnormality was associated with a lesser risk of neonatal complication. Further prospective study is essential to validate these findings. MDPI 2020-09-24 2020-10 /pmc/articles/PMC7579185/ /pubmed/32987806 http://dx.doi.org/10.3390/ijerph17196990 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kalok, Aida
Ong, Ming Yean
Hasrori, Aqilah
Chiang, Ker Shing
Yazim, Fatin
Baharuddin, Salahuddin
Rahman, Rahana Abdul
Shah, Shamsul Azhar
Aziz, Nor Haslinda Abd
Ahmad, Shuhaila
Ismail, Nor Azlin Mohamed
Correlation between Oral Glucose Tolerance Test Abnormalities and Adverse Pregnancy Outcomes in Gestational Diabetes: A Cross-Sectional Study
title Correlation between Oral Glucose Tolerance Test Abnormalities and Adverse Pregnancy Outcomes in Gestational Diabetes: A Cross-Sectional Study
title_full Correlation between Oral Glucose Tolerance Test Abnormalities and Adverse Pregnancy Outcomes in Gestational Diabetes: A Cross-Sectional Study
title_fullStr Correlation between Oral Glucose Tolerance Test Abnormalities and Adverse Pregnancy Outcomes in Gestational Diabetes: A Cross-Sectional Study
title_full_unstemmed Correlation between Oral Glucose Tolerance Test Abnormalities and Adverse Pregnancy Outcomes in Gestational Diabetes: A Cross-Sectional Study
title_short Correlation between Oral Glucose Tolerance Test Abnormalities and Adverse Pregnancy Outcomes in Gestational Diabetes: A Cross-Sectional Study
title_sort correlation between oral glucose tolerance test abnormalities and adverse pregnancy outcomes in gestational diabetes: a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579185/
https://www.ncbi.nlm.nih.gov/pubmed/32987806
http://dx.doi.org/10.3390/ijerph17196990
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