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Synthesis and Biological Activity of a Bis-steroid-methanocyclobuta-naphthalene-dione Derivative against Ischemia/Reperfusion Injury via Calcium Channel Activation
Background: There is some experimental data on the effect exerted by some steroid derivatives against ischemia/reperfusion injury; however, the molecular mechanism is very confusing, perhaps this phenomenon could be due to the protocols used and/or differences in the chemical structure of each one o...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bentham Science Publishers
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579317/ https://www.ncbi.nlm.nih.gov/pubmed/31580254 http://dx.doi.org/10.2174/1871523018666191003152854 |
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author | Lauro, Figueroa-Valverde Francisco, Diaz-Cedillo Marcela, Rosas-Nexticapa Virginia, Mateu-Armand Alejandra, Garcimarero-Espino E. Maria, Lopez-Ramos Lenin, Hau-Heredia Yaritza, Borges-Ballote Jhair, Cabrera-Tuz |
author_facet | Lauro, Figueroa-Valverde Francisco, Diaz-Cedillo Marcela, Rosas-Nexticapa Virginia, Mateu-Armand Alejandra, Garcimarero-Espino E. Maria, Lopez-Ramos Lenin, Hau-Heredia Yaritza, Borges-Ballote Jhair, Cabrera-Tuz |
author_sort | Lauro, Figueroa-Valverde |
collection | PubMed |
description | Background: There is some experimental data on the effect exerted by some steroid derivatives against ischemia/reperfusion injury; however, the molecular mechanism is very confusing, perhaps this phenomenon could be due to the protocols used and/or differences in the chemical structure of each one of the steroid derivatives. Objectives: The aim of this study was to synthesize a new bis-steroid-methanocyclobuta-naphthalene-dione derivative using some tools chemical. Methodology: The biological activity exerted by the bis-steroid-methanocyclobuta-naphthalene-dione derivative against ischemia/reperfusion injury was evaluated in an isolated heart model using noradrenaline, milrinone, dobutamine, levosimendan, and Bay-K-8644 as controls. In addition, other alternative experiments were carried out to evaluate the biological activity induced by the bis-steroid-methanocyclobuta-naphthalene-dione derivative against left ventricular pressure in the absence or presence of nifedipine. Results: The results showed that 1) the bis-steroid-methanocyclobuta-naphthalene-dione derivative significantly decreases the ischemia-reperfusion injury translated as a decrease in the the infarct area in a similar manner to levosimendan drug; 2) both bis-steroid-methanocyclobuta-naphthalene-dione and Bay-K-8644 increase the left ventricular pressure and 3) the biological activity exerted by bis-steroid-methanocyclobuta-naphthalene-dione derivative against left ventricular pressure is inhibited by nifedipine. Conclusion: In conclusion, the bis-steroid-methanocyclobuta-naphthalene-dione derivative decreases the area of infarction and increases left ventricle pressure via calcium channels activation; this phenomenon could constitute a new therapy for ischemia/reperfusion injury. |
format | Online Article Text |
id | pubmed-7579317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-75793172020-11-30 Synthesis and Biological Activity of a Bis-steroid-methanocyclobuta-naphthalene-dione Derivative against Ischemia/Reperfusion Injury via Calcium Channel Activation Lauro, Figueroa-Valverde Francisco, Diaz-Cedillo Marcela, Rosas-Nexticapa Virginia, Mateu-Armand Alejandra, Garcimarero-Espino E. Maria, Lopez-Ramos Lenin, Hau-Heredia Yaritza, Borges-Ballote Jhair, Cabrera-Tuz Antiinflamm Antiallergy Agents Med Chem Article Background: There is some experimental data on the effect exerted by some steroid derivatives against ischemia/reperfusion injury; however, the molecular mechanism is very confusing, perhaps this phenomenon could be due to the protocols used and/or differences in the chemical structure of each one of the steroid derivatives. Objectives: The aim of this study was to synthesize a new bis-steroid-methanocyclobuta-naphthalene-dione derivative using some tools chemical. Methodology: The biological activity exerted by the bis-steroid-methanocyclobuta-naphthalene-dione derivative against ischemia/reperfusion injury was evaluated in an isolated heart model using noradrenaline, milrinone, dobutamine, levosimendan, and Bay-K-8644 as controls. In addition, other alternative experiments were carried out to evaluate the biological activity induced by the bis-steroid-methanocyclobuta-naphthalene-dione derivative against left ventricular pressure in the absence or presence of nifedipine. Results: The results showed that 1) the bis-steroid-methanocyclobuta-naphthalene-dione derivative significantly decreases the ischemia-reperfusion injury translated as a decrease in the the infarct area in a similar manner to levosimendan drug; 2) both bis-steroid-methanocyclobuta-naphthalene-dione and Bay-K-8644 increase the left ventricular pressure and 3) the biological activity exerted by bis-steroid-methanocyclobuta-naphthalene-dione derivative against left ventricular pressure is inhibited by nifedipine. Conclusion: In conclusion, the bis-steroid-methanocyclobuta-naphthalene-dione derivative decreases the area of infarction and increases left ventricle pressure via calcium channels activation; this phenomenon could constitute a new therapy for ischemia/reperfusion injury. Bentham Science Publishers 2020-12 2020-12 /pmc/articles/PMC7579317/ /pubmed/31580254 http://dx.doi.org/10.2174/1871523018666191003152854 Text en © 2020 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Lauro, Figueroa-Valverde Francisco, Diaz-Cedillo Marcela, Rosas-Nexticapa Virginia, Mateu-Armand Alejandra, Garcimarero-Espino E. Maria, Lopez-Ramos Lenin, Hau-Heredia Yaritza, Borges-Ballote Jhair, Cabrera-Tuz Synthesis and Biological Activity of a Bis-steroid-methanocyclobuta-naphthalene-dione Derivative against Ischemia/Reperfusion Injury via Calcium Channel Activation |
title | Synthesis and Biological Activity of a Bis-steroid-methanocyclobuta-naphthalene-dione Derivative against Ischemia/Reperfusion Injury via Calcium Channel Activation |
title_full | Synthesis and Biological Activity of a Bis-steroid-methanocyclobuta-naphthalene-dione Derivative against Ischemia/Reperfusion Injury via Calcium Channel Activation |
title_fullStr | Synthesis and Biological Activity of a Bis-steroid-methanocyclobuta-naphthalene-dione Derivative against Ischemia/Reperfusion Injury via Calcium Channel Activation |
title_full_unstemmed | Synthesis and Biological Activity of a Bis-steroid-methanocyclobuta-naphthalene-dione Derivative against Ischemia/Reperfusion Injury via Calcium Channel Activation |
title_short | Synthesis and Biological Activity of a Bis-steroid-methanocyclobuta-naphthalene-dione Derivative against Ischemia/Reperfusion Injury via Calcium Channel Activation |
title_sort | synthesis and biological activity of a bis-steroid-methanocyclobuta-naphthalene-dione derivative against ischemia/reperfusion injury via calcium channel activation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579317/ https://www.ncbi.nlm.nih.gov/pubmed/31580254 http://dx.doi.org/10.2174/1871523018666191003152854 |
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