Maternal Immunological Adaptation During Normal Pregnancy

The risk and severity of specific infections are increased during pregnancy due to a combination of physiological and immunological changes. Characterizing the maternal immune system during pregnancy is important to understand how the maternal immune system maintains tolerance towards the allogeneic...

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Autores principales: Abu-Raya, Bahaa, Michalski, Christina, Sadarangani, Manish, Lavoie, Pascal M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579415/
https://www.ncbi.nlm.nih.gov/pubmed/33133091
http://dx.doi.org/10.3389/fimmu.2020.575197
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author Abu-Raya, Bahaa
Michalski, Christina
Sadarangani, Manish
Lavoie, Pascal M.
author_facet Abu-Raya, Bahaa
Michalski, Christina
Sadarangani, Manish
Lavoie, Pascal M.
author_sort Abu-Raya, Bahaa
collection PubMed
description The risk and severity of specific infections are increased during pregnancy due to a combination of physiological and immunological changes. Characterizing the maternal immune system during pregnancy is important to understand how the maternal immune system maintains tolerance towards the allogeneic fetus. This may also inform strategies to prevent maternal fatalities due to infections and optimize maternal vaccination to best protect the mother-fetus dyad and the infant after birth. In this review, we describe what is known about the immunological changes that occur during a normal pregnancy.
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spelling pubmed-75794152020-10-30 Maternal Immunological Adaptation During Normal Pregnancy Abu-Raya, Bahaa Michalski, Christina Sadarangani, Manish Lavoie, Pascal M. Front Immunol Immunology The risk and severity of specific infections are increased during pregnancy due to a combination of physiological and immunological changes. Characterizing the maternal immune system during pregnancy is important to understand how the maternal immune system maintains tolerance towards the allogeneic fetus. This may also inform strategies to prevent maternal fatalities due to infections and optimize maternal vaccination to best protect the mother-fetus dyad and the infant after birth. In this review, we describe what is known about the immunological changes that occur during a normal pregnancy. Frontiers Media S.A. 2020-10-07 /pmc/articles/PMC7579415/ /pubmed/33133091 http://dx.doi.org/10.3389/fimmu.2020.575197 Text en Copyright © 2020 Abu-Raya, Michalski, Sadarangani and Lavoie http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Abu-Raya, Bahaa
Michalski, Christina
Sadarangani, Manish
Lavoie, Pascal M.
Maternal Immunological Adaptation During Normal Pregnancy
title Maternal Immunological Adaptation During Normal Pregnancy
title_full Maternal Immunological Adaptation During Normal Pregnancy
title_fullStr Maternal Immunological Adaptation During Normal Pregnancy
title_full_unstemmed Maternal Immunological Adaptation During Normal Pregnancy
title_short Maternal Immunological Adaptation During Normal Pregnancy
title_sort maternal immunological adaptation during normal pregnancy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579415/
https://www.ncbi.nlm.nih.gov/pubmed/33133091
http://dx.doi.org/10.3389/fimmu.2020.575197
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AT michalskichristina maternalimmunologicaladaptationduringnormalpregnancy
AT sadaranganimanish maternalimmunologicaladaptationduringnormalpregnancy
AT lavoiepascalm maternalimmunologicaladaptationduringnormalpregnancy

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