The role of Langerhans cells in epidermal homeostasis and pathogenesis of psoriasis

The skin is the main barrier between the human body and the outside world, which not only plays the role of a physical barrier but also functions as the first line of defence of immunology. Langerhans cells (LCs), as dendritic cells (DC) that play an important role in the immune system, are mainly d...

Descripción completa

Detalles Bibliográficos
Autores principales: Yan, Bei, Liu, Nian, Li, Jie, Li, Jiaoduan, Zhu, Wu, Kuang, Yehong, Chen, Xiang, Peng, Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579693/
https://www.ncbi.nlm.nih.gov/pubmed/32916775
http://dx.doi.org/10.1111/jcmm.15834
_version_ 1783598648374853632
author Yan, Bei
Liu, Nian
Li, Jie
Li, Jiaoduan
Zhu, Wu
Kuang, Yehong
Chen, Xiang
Peng, Cong
author_facet Yan, Bei
Liu, Nian
Li, Jie
Li, Jiaoduan
Zhu, Wu
Kuang, Yehong
Chen, Xiang
Peng, Cong
author_sort Yan, Bei
collection PubMed
description The skin is the main barrier between the human body and the outside world, which not only plays the role of a physical barrier but also functions as the first line of defence of immunology. Langerhans cells (LCs), as dendritic cells (DC) that play an important role in the immune system, are mainly distributed in the epidermis. This review focuses on the role of these epidermal LCs in regulating skin threats (such as microorganisms, ultraviolet radiation and allergens), especially psoriasis. Since human and mouse skin DC subsets share common ontogenetic characteristics, we can further explore the role of LCs in psoriatic inflammation.
format Online
Article
Text
id pubmed-7579693
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-75796932020-10-27 The role of Langerhans cells in epidermal homeostasis and pathogenesis of psoriasis Yan, Bei Liu, Nian Li, Jie Li, Jiaoduan Zhu, Wu Kuang, Yehong Chen, Xiang Peng, Cong J Cell Mol Med Reviews The skin is the main barrier between the human body and the outside world, which not only plays the role of a physical barrier but also functions as the first line of defence of immunology. Langerhans cells (LCs), as dendritic cells (DC) that play an important role in the immune system, are mainly distributed in the epidermis. This review focuses on the role of these epidermal LCs in regulating skin threats (such as microorganisms, ultraviolet radiation and allergens), especially psoriasis. Since human and mouse skin DC subsets share common ontogenetic characteristics, we can further explore the role of LCs in psoriatic inflammation. John Wiley and Sons Inc. 2020-09-11 2020-10 /pmc/articles/PMC7579693/ /pubmed/32916775 http://dx.doi.org/10.1111/jcmm.15834 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Yan, Bei
Liu, Nian
Li, Jie
Li, Jiaoduan
Zhu, Wu
Kuang, Yehong
Chen, Xiang
Peng, Cong
The role of Langerhans cells in epidermal homeostasis and pathogenesis of psoriasis
title The role of Langerhans cells in epidermal homeostasis and pathogenesis of psoriasis
title_full The role of Langerhans cells in epidermal homeostasis and pathogenesis of psoriasis
title_fullStr The role of Langerhans cells in epidermal homeostasis and pathogenesis of psoriasis
title_full_unstemmed The role of Langerhans cells in epidermal homeostasis and pathogenesis of psoriasis
title_short The role of Langerhans cells in epidermal homeostasis and pathogenesis of psoriasis
title_sort role of langerhans cells in epidermal homeostasis and pathogenesis of psoriasis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579693/
https://www.ncbi.nlm.nih.gov/pubmed/32916775
http://dx.doi.org/10.1111/jcmm.15834
work_keys_str_mv AT yanbei theroleoflangerhanscellsinepidermalhomeostasisandpathogenesisofpsoriasis
AT liunian theroleoflangerhanscellsinepidermalhomeostasisandpathogenesisofpsoriasis
AT lijie theroleoflangerhanscellsinepidermalhomeostasisandpathogenesisofpsoriasis
AT lijiaoduan theroleoflangerhanscellsinepidermalhomeostasisandpathogenesisofpsoriasis
AT zhuwu theroleoflangerhanscellsinepidermalhomeostasisandpathogenesisofpsoriasis
AT kuangyehong theroleoflangerhanscellsinepidermalhomeostasisandpathogenesisofpsoriasis
AT chenxiang theroleoflangerhanscellsinepidermalhomeostasisandpathogenesisofpsoriasis
AT pengcong theroleoflangerhanscellsinepidermalhomeostasisandpathogenesisofpsoriasis
AT yanbei roleoflangerhanscellsinepidermalhomeostasisandpathogenesisofpsoriasis
AT liunian roleoflangerhanscellsinepidermalhomeostasisandpathogenesisofpsoriasis
AT lijie roleoflangerhanscellsinepidermalhomeostasisandpathogenesisofpsoriasis
AT lijiaoduan roleoflangerhanscellsinepidermalhomeostasisandpathogenesisofpsoriasis
AT zhuwu roleoflangerhanscellsinepidermalhomeostasisandpathogenesisofpsoriasis
AT kuangyehong roleoflangerhanscellsinepidermalhomeostasisandpathogenesisofpsoriasis
AT chenxiang roleoflangerhanscellsinepidermalhomeostasisandpathogenesisofpsoriasis
AT pengcong roleoflangerhanscellsinepidermalhomeostasisandpathogenesisofpsoriasis

Ejemplares similares