KIT ligand produced by limbal niche cells under control of SOX10 maintains limbal epithelial stem cell survival by activating the KIT/AKT signalling pathway

Homeostasis and function of limbal epithelial stem cells (LESCs) rely on the limbal niche, which, if dysfunctional, leads to limbal epithelial stem cell deficiency (LSCD) and impaired vision. Hence, recovery of niche function is a principal therapeutic goal in LSCD, but the molecular mechanisms of l...

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Detalles Bibliográficos
Autores principales: Su, Zhongyuan, Wang, Jing, Lai, Qinghua, Zhao, Huanyu, Hou, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579694/
https://www.ncbi.nlm.nih.gov/pubmed/32914934
http://dx.doi.org/10.1111/jcmm.15830

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