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Endogenous motion of liver correlates to the severity of portal hypertension

BACKGROUND: Degree of portal hypertension (PH) is the most important prognostic factor for the decompensation of liver cirrhosis and death, therefore adequate care for patients with liver cirrhosis requires timely detection and evaluation of the presence of clinically significant PH (CSPH) and sever...

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Autores principales: Gelman, Sigita, Sakalauskas, Andrius, Zykus, Romanas, Pranculis, Andrius, Jurkonis, Rytis, Kuliavienė, Irma, Lukoševičius, Arūnas, Kupčinskas, Limas, Kupčinskas, Juozas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579755/
https://www.ncbi.nlm.nih.gov/pubmed/33132638
http://dx.doi.org/10.3748/wjg.v26.i38.5836
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author Gelman, Sigita
Sakalauskas, Andrius
Zykus, Romanas
Pranculis, Andrius
Jurkonis, Rytis
Kuliavienė, Irma
Lukoševičius, Arūnas
Kupčinskas, Limas
Kupčinskas, Juozas
author_facet Gelman, Sigita
Sakalauskas, Andrius
Zykus, Romanas
Pranculis, Andrius
Jurkonis, Rytis
Kuliavienė, Irma
Lukoševičius, Arūnas
Kupčinskas, Limas
Kupčinskas, Juozas
author_sort Gelman, Sigita
collection PubMed
description BACKGROUND: Degree of portal hypertension (PH) is the most important prognostic factor for the decompensation of liver cirrhosis and death, therefore adequate care for patients with liver cirrhosis requires timely detection and evaluation of the presence of clinically significant PH (CSPH) and severe PH (SPH). As the most accurate method for the assessment of PH is an invasive direct measurement of hepatic venous pressure gradient (HVPG), the search for non-invasive methods to diagnose these conditions is actively ongoing. AIM: To evaluate the feasibility of parameters of endogenously induced displacements and strain of liver to assess degree of PH. METHODS: Of 36 patients with liver cirrhosis and measured HVPG were included in the case-control study. Endogenous motion of the liver was characterized by derived parameters of region average tissue displacement signal (d(antero), d(r)(etro), d(RMS)) and results of endogenous tissue strain imaging using specific radiofrequency signal processing algorithm. Average endogenous strain µ and standard deviation σ of strain were assessed in the regions of interest (ROI) (1 cm × 1 cm and 2 cm × 2 cm in size) and different frequency subbands of endogenous motion (0-10 Hz and 10-20 Hz). RESULTS: Four parameters showed statistically significant (P < 0.05) correlation with HVPG measurement. The strongest correlation was obtained for the standard deviation of strain (estimated at 0-10 Hz and 2 cm × 2 cm ROI size). Three parameters showed statistically significant differences between patient groups with CSPH, but only d(retro) showed significant results in SPH analysis. According to ROC analysis area under the curve (AUC) of the σ(ROI[0…10Hz, 2 cm × 2 cm]) parameter reached 0.71 (P = 0.036) for the diagnosis of CSPH; with a cut-off value of 1.28 μm/cm providing 73% sensitivity and 70% specificity. AUC for the diagnosis of CSPH for µ(ROI[0…10Hz, 1 cm × 1 cm]) was 0.78 (P = 0.0024); with a cut-off value of 3.92 μm/cm providing 73% sensitivity and 80% specificity. D(retro) parameter had an AUC of 0.86 (P = 0.0001) for the diagnosis of CSPH and 0.84 (P = 0.0001) for the diagnosis of SPH. A cut-off value of -132.34 μm yielded 100% sensitivity for both conditions, whereas specificity was 80% and 72% for CSPH and SPH respectively. CONCLUSION: The parameters of endogenously induced displacements and strain of the liver correlated with HVPG and might be used for non-invasive diagnosis of PH.
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spelling pubmed-75797552020-10-29 Endogenous motion of liver correlates to the severity of portal hypertension Gelman, Sigita Sakalauskas, Andrius Zykus, Romanas Pranculis, Andrius Jurkonis, Rytis Kuliavienė, Irma Lukoševičius, Arūnas Kupčinskas, Limas Kupčinskas, Juozas World J Gastroenterol Case Control Study BACKGROUND: Degree of portal hypertension (PH) is the most important prognostic factor for the decompensation of liver cirrhosis and death, therefore adequate care for patients with liver cirrhosis requires timely detection and evaluation of the presence of clinically significant PH (CSPH) and severe PH (SPH). As the most accurate method for the assessment of PH is an invasive direct measurement of hepatic venous pressure gradient (HVPG), the search for non-invasive methods to diagnose these conditions is actively ongoing. AIM: To evaluate the feasibility of parameters of endogenously induced displacements and strain of liver to assess degree of PH. METHODS: Of 36 patients with liver cirrhosis and measured HVPG were included in the case-control study. Endogenous motion of the liver was characterized by derived parameters of region average tissue displacement signal (d(antero), d(r)(etro), d(RMS)) and results of endogenous tissue strain imaging using specific radiofrequency signal processing algorithm. Average endogenous strain µ and standard deviation σ of strain were assessed in the regions of interest (ROI) (1 cm × 1 cm and 2 cm × 2 cm in size) and different frequency subbands of endogenous motion (0-10 Hz and 10-20 Hz). RESULTS: Four parameters showed statistically significant (P < 0.05) correlation with HVPG measurement. The strongest correlation was obtained for the standard deviation of strain (estimated at 0-10 Hz and 2 cm × 2 cm ROI size). Three parameters showed statistically significant differences between patient groups with CSPH, but only d(retro) showed significant results in SPH analysis. According to ROC analysis area under the curve (AUC) of the σ(ROI[0…10Hz, 2 cm × 2 cm]) parameter reached 0.71 (P = 0.036) for the diagnosis of CSPH; with a cut-off value of 1.28 μm/cm providing 73% sensitivity and 70% specificity. AUC for the diagnosis of CSPH for µ(ROI[0…10Hz, 1 cm × 1 cm]) was 0.78 (P = 0.0024); with a cut-off value of 3.92 μm/cm providing 73% sensitivity and 80% specificity. D(retro) parameter had an AUC of 0.86 (P = 0.0001) for the diagnosis of CSPH and 0.84 (P = 0.0001) for the diagnosis of SPH. A cut-off value of -132.34 μm yielded 100% sensitivity for both conditions, whereas specificity was 80% and 72% for CSPH and SPH respectively. CONCLUSION: The parameters of endogenously induced displacements and strain of the liver correlated with HVPG and might be used for non-invasive diagnosis of PH. Baishideng Publishing Group Inc 2020-10-14 2020-10-14 /pmc/articles/PMC7579755/ /pubmed/33132638 http://dx.doi.org/10.3748/wjg.v26.i38.5836 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Case Control Study
Gelman, Sigita
Sakalauskas, Andrius
Zykus, Romanas
Pranculis, Andrius
Jurkonis, Rytis
Kuliavienė, Irma
Lukoševičius, Arūnas
Kupčinskas, Limas
Kupčinskas, Juozas
Endogenous motion of liver correlates to the severity of portal hypertension
title Endogenous motion of liver correlates to the severity of portal hypertension
title_full Endogenous motion of liver correlates to the severity of portal hypertension
title_fullStr Endogenous motion of liver correlates to the severity of portal hypertension
title_full_unstemmed Endogenous motion of liver correlates to the severity of portal hypertension
title_short Endogenous motion of liver correlates to the severity of portal hypertension
title_sort endogenous motion of liver correlates to the severity of portal hypertension
topic Case Control Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579755/
https://www.ncbi.nlm.nih.gov/pubmed/33132638
http://dx.doi.org/10.3748/wjg.v26.i38.5836
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