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In vivo vaccination with cell line-derived whole tumor lysates: neoantigen quality, not quantity matters
BACKGROUND: Cancer vaccines provide a complex source of neoantigens. Still, increasing evidence reveals that the neoantigen quality rather than the quantity is predictive for treatment outcome. METHODS: Using the preclinical Mlh1(−/−) tumor model, we performed a side-by side comparison of two autolo...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579816/ https://www.ncbi.nlm.nih.gov/pubmed/33087163 http://dx.doi.org/10.1186/s12967-020-02570-y |