Cargando…

Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma

BACKGROUND: Glioblastoma (GBM) is a universally lethal tumor with frequently overexpressed or mutated epidermal growth factor receptor (EGFR). NADPH quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase Pi 1 (GSTP1) are commonly upregulated in GBM. NQO1 and GSTP1 decrease the formation of re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lei, Kecheng, Gu, Xiaoxia, Alvarado, Alvaro G., Du, Yuhong, Luo, Shilin, Ahn, Eun Hee, Kang, Seong Su, Ji, Bing, Liu, Xia, Mao, Hui, Fu, Haian, Kornblum, Harley I., Jin, Lingjing, Li, Hua, Ye, Keqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579906/ https://www.ncbi.nlm.nih.gov/pubmed/33087132 http://dx.doi.org/10.1186/s13045-020-00979-y

Ejemplares similares

C/EBPβ mediates NQO1 and GSTP1 anti-oxidative reductases expression in glioblastoma, promoting brain tumor proliferation
por: Lei, Kecheng, et al.
Publicado: (2020)

NQO1 Is Regulated by PTEN in Glioblastoma, Mediating Cell Proliferation and Oxidative Stress
por: Luo, Shilin, et al.
Publicado: (2018)

Association of the GSTP1 and NQO1 Polymorphisms and Head and Neck Squamous Cell Carcinoma Risk
por: Cho, Chang Gun, et al.
Publicado: (2006)

OTEH-8. Pathway-based approach reveals sensitivity to radiation when targeting E2F1 in Glioblastoma
por: Alvarado, Alvaro, et al.
Publicado: (2021)

Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China
por: Guo, Xiuchan, et al.
Publicado: (2010)

R-sulforaphane modulates the expression profile of AhR, ERα, Nrf2, NQO1, and GSTP in human breast cell lines
por: Licznerska, Barbara, et al.
Publicado: (2020)

Discovery of Isoplumbagin as a Novel NQO1 Substrate and Anti-Cancer Quinone
por: Tsao, Yen-Chi, et al.
Publicado: (2020)

Redox modulation of NQO1
por: Siegel, David, et al.
Publicado: (2018)

A polymorphism in NAD(P)H:quinone oxidoreductase (NQO1): relationship of a homozygous mutation at position 609 of the NQO1 cDNA to NQO1 activity.
por: Ross, D., et al.
Publicado: (1996)

Pathway-based Approach Reveals Differential Sensitivity to E2F1 Inhibition in Glioblastoma
por: Alvarado, Alvaro G., et al.
Publicado: (2022)

Implications of NQO1 in cancer therapy
por: Oh, Eun-Taex, et al.
Publicado: (2015)

The Role of NQO1 in Ovarian Cancer
por: Tossetta, Giovanni, et al.
Publicado: (2023)

Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1
por: Salido, Eduardo, et al.
Publicado: (2022)

Correlation between the expression of DNMT1, and GSTP1 and APC, and the methylation status of GSTP1 and APC in association with their clinical significance in prostate cancer
por: ZHANG, WEIJIE, et al.
Publicado: (2015)

Activation of NQO1 in NQO1*2 polymorphic human leukemic HL-60 cells by diet-derived sulforaphane
por: Wu, Joseph M., et al.
Publicado: (2016)

NQO1 Binds and Supports SIRT1 Function
por: Tsvetkov, Peter, et al.
Publicado: (2021)

Pharmacokinetic and safety evaluation of MB12066, an NQO1 substrate
por: Lee, Hae Won, et al.
Publicado: (2017)

NQO1 protects against clioquinol toxicity
por: Chhetri, Jamuna, et al.
Publicado: (2022)

GSTM1, GSTT1 and GSTP1 Polymorphisms in the Korean Population
por: Cho, Hyun-Jung, et al.
Publicado: (2005)

Co-amplification of Phosphoinositide 3-kinase enhancer A and Cyclin-dependent kinase 4 Triggers Glioblastoma Progression
por: Qi, Qi, et al.
Publicado: (2017)

LncRNA Nqo1-AS1 Attenuates Cigarette Smoke-Induced Oxidative Stress by Upregulating its Natural Antisense Transcript Nqo1
por: Zhang, Haiyun, et al.
Publicado: (2021)

Combined effects of GSTP1 and MRP1 in melanoma drug resistance
por: Depeille, P, et al.
Publicado: (2005)

Immunohistochemical detection of P-glycoprotein and GSTP1-1 in testis cancer.
por: Katagiri, A., et al.
Publicado: (1993)

Frequency of NAT2 and GSTP1 polymorphisms in the Kazakh population
por: Iskakova, Aisha, et al.
Publicado: (2014)

Associations of NQO1 C609T and NQO1 C465T polymorphisms with acute leukemia risk: a PRISMA-compliant meta-analysis
por: He, Hairong, et al.
Publicado: (2017)

NQO1 C609T polymorphism and esophageal cancer risk: a HuGE review and meta-analysis
por: Yanling, Hu, et al.
Publicado: (2013)

Short-term Exposure to 50-Hz Electromagnetic Field and Alterations in NQO1 and NQO2 Expression in MCF-7 Cells
por: Mahmoudinasab, Hamideh, et al.
Publicado: (2016)

Association of HMOX1 and NQO1 Polymorphisms with Metabolic Syndrome Components
por: Martínez-Hernández, Angélica, et al.
Publicado: (2015)

NQO1 inhibits proteasome-mediated degradation of HIF-1α
por: Oh, Eun-Taex, et al.
Publicado: (2016)

The prognostic impact of GSTM1/GSTP1 genetic variants in bladder Cancer
por: Albarakati, Nada, et al.
Publicado: (2019)

NQO1/CPT1A promotes the progression of pancreatic adenocarcinoma via fatty acid oxidation: NQO1/CPT1A promotes PAAD via FAO
por: Xu, Ran, et al.
Publicado: (2023)

Arsenic Methylation, GSTT1, GSTM1, GSTP1 Polymorphisms, and Skin Lesions
por: McCarty, Kathleen M., et al.
Publicado: (2007)

Clinical implications of high NQO1 expression in breast cancers
por: Yang, Yang, et al.
Publicado: (2014)

Clinicopathological implications of NQO1 overexpression in the prognosis of pancreatic adenocarcinoma
por: Ji, Meiying, et al.
Publicado: (2017)

The diverse functionality of NQO1 and its roles in redox control
por: Ross, David, et al.
Publicado: (2021)

Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound
por: Giovannucci, Tatiana A., et al.
Publicado: (2021)

DNA Methylation of GSTP1 in Human Prostate Tissues: Pyrosequencing Analysis
por: Yoon, Hyung-Yoon, et al.
Publicado: (2012)

GSTP1 Methylation and Protein Expression in Prostate Cancer: Diagnostic Implications
por: Martignano, Filippo, et al.
Publicado: (2016)

GSTP1 polymorphism predicts treatment outcome and toxicities for breast cancer
por: Ma, Jie, et al.
Publicado: (2017)

Prognostic significance of GSTP1 in patients with triple negative breast cancer
por: Chen, Guanglei, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_k9fn0lqrlgcu3f44oh7o1g2ovd