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Correlation of clinical signs and symptoms of Behçet’s disease with mean platelet volume (MPV) and red cell distribution width (RDW)

BACKGROUND: A strong correlation was previously found between mean platelet volume (MPV), red blood cell distribution width (RDW), and the severity of signs and symptoms in patients suffering from inflammatory and autoimmune diseases. The current study evaluated these correlations in patients with B...

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Autores principales: Masoumi, Maryam, Shadmanfar, Soraya, Davatchi, Fereydoun, Shahram, Farhad, Akhlagi, Massoomeh, Faezi, Tahereh, Kavosi, Hoda, Moradi, Soroush, Balasi, Javad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579941/
https://www.ncbi.nlm.nih.gov/pubmed/33087144
http://dx.doi.org/10.1186/s13023-020-01588-1
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author Masoumi, Maryam
Shadmanfar, Soraya
Davatchi, Fereydoun
Shahram, Farhad
Akhlagi, Massoomeh
Faezi, Tahereh
Kavosi, Hoda
Moradi, Soroush
Balasi, Javad
author_facet Masoumi, Maryam
Shadmanfar, Soraya
Davatchi, Fereydoun
Shahram, Farhad
Akhlagi, Massoomeh
Faezi, Tahereh
Kavosi, Hoda
Moradi, Soroush
Balasi, Javad
author_sort Masoumi, Maryam
collection PubMed
description BACKGROUND: A strong correlation was previously found between mean platelet volume (MPV), red blood cell distribution width (RDW), and the severity of signs and symptoms in patients suffering from inflammatory and autoimmune diseases. The current study evaluated these correlations in patients with Behçet’s disease (BD) as well the relationship between MPV and RDW and disease activity score on the Iranian Behçet’s Disease Dynamic Activity Measurement (IBDDAM). METHODS: This cross-sectional study included 319 patients with BD for whom demographic and epidemiological data, IBDDAM scores, and duration of illness was recorded. Blood samples were then obtained and the relationships between their disease status and manifestations and their laboratory parameters were evaluated with statistical models to find possible correlations. RESULTS: Our analysis showed a significantly higher RDW in patients with BD who had ocular manifestations (p < 0.001) and oral aphthae (p = 0.004). Patients with active BD had higher RDW (p < 0.001) and MPV (p < 0.001) in comparison to those with currently inactive BD. Similarly, patients who had any type of ocular manifestation had higher RDW (p < 0.001) and MPV (p < 0.001). Regression analyses identified a statistically significant model for the effect of RDW and MPV in predicting active BD status (p < 0.001), as well as its significant relationship with active ocular manifestations (p < 0.001). CONCLUSION: BD was found to be associated with an increase in MPV and RDW, particularly during active phases. RDW and MPV were also found to have predictive value for screening to detect BD activity and its ocular complications.
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spelling pubmed-75799412020-10-22 Correlation of clinical signs and symptoms of Behçet’s disease with mean platelet volume (MPV) and red cell distribution width (RDW) Masoumi, Maryam Shadmanfar, Soraya Davatchi, Fereydoun Shahram, Farhad Akhlagi, Massoomeh Faezi, Tahereh Kavosi, Hoda Moradi, Soroush Balasi, Javad Orphanet J Rare Dis Research BACKGROUND: A strong correlation was previously found between mean platelet volume (MPV), red blood cell distribution width (RDW), and the severity of signs and symptoms in patients suffering from inflammatory and autoimmune diseases. The current study evaluated these correlations in patients with Behçet’s disease (BD) as well the relationship between MPV and RDW and disease activity score on the Iranian Behçet’s Disease Dynamic Activity Measurement (IBDDAM). METHODS: This cross-sectional study included 319 patients with BD for whom demographic and epidemiological data, IBDDAM scores, and duration of illness was recorded. Blood samples were then obtained and the relationships between their disease status and manifestations and their laboratory parameters were evaluated with statistical models to find possible correlations. RESULTS: Our analysis showed a significantly higher RDW in patients with BD who had ocular manifestations (p < 0.001) and oral aphthae (p = 0.004). Patients with active BD had higher RDW (p < 0.001) and MPV (p < 0.001) in comparison to those with currently inactive BD. Similarly, patients who had any type of ocular manifestation had higher RDW (p < 0.001) and MPV (p < 0.001). Regression analyses identified a statistically significant model for the effect of RDW and MPV in predicting active BD status (p < 0.001), as well as its significant relationship with active ocular manifestations (p < 0.001). CONCLUSION: BD was found to be associated with an increase in MPV and RDW, particularly during active phases. RDW and MPV were also found to have predictive value for screening to detect BD activity and its ocular complications. BioMed Central 2020-10-21 /pmc/articles/PMC7579941/ /pubmed/33087144 http://dx.doi.org/10.1186/s13023-020-01588-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Masoumi, Maryam
Shadmanfar, Soraya
Davatchi, Fereydoun
Shahram, Farhad
Akhlagi, Massoomeh
Faezi, Tahereh
Kavosi, Hoda
Moradi, Soroush
Balasi, Javad
Correlation of clinical signs and symptoms of Behçet’s disease with mean platelet volume (MPV) and red cell distribution width (RDW)
title Correlation of clinical signs and symptoms of Behçet’s disease with mean platelet volume (MPV) and red cell distribution width (RDW)
title_full Correlation of clinical signs and symptoms of Behçet’s disease with mean platelet volume (MPV) and red cell distribution width (RDW)
title_fullStr Correlation of clinical signs and symptoms of Behçet’s disease with mean platelet volume (MPV) and red cell distribution width (RDW)
title_full_unstemmed Correlation of clinical signs and symptoms of Behçet’s disease with mean platelet volume (MPV) and red cell distribution width (RDW)
title_short Correlation of clinical signs and symptoms of Behçet’s disease with mean platelet volume (MPV) and red cell distribution width (RDW)
title_sort correlation of clinical signs and symptoms of behçet’s disease with mean platelet volume (mpv) and red cell distribution width (rdw)
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7579941/
https://www.ncbi.nlm.nih.gov/pubmed/33087144
http://dx.doi.org/10.1186/s13023-020-01588-1
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