Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation

BACKGROUND: Wnt signaling is an evolutionarily conserved developmental pathway that is frequently hyperactivated in cancer. While multiple protein-coding genes regulated by Wnt signaling are known, the functional lncRNAs regulated by Wnt signaling have not been systematically characterized. METHODS:...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Shiyang, Harmston, Nathan, Glaser, Trudy Lee, Wong, Yunka, Zhong, Zheng, Madan, Babita, Virshup, David M., Petretto, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580003/
https://www.ncbi.nlm.nih.gov/pubmed/33092630
http://dx.doi.org/10.1186/s13073-020-00788-5

Ejemplares similares

Ejemplares similares