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NIMBus: a negative binomial regression based Integrative Method for mutation Burden Analysis

BACKGROUND: Identifying frequently mutated regions is a key approach to discover DNA elements influencing cancer progression. However, it is challenging to identify these burdened regions due to mutation rate heterogeneity across the genome and across different individuals. Moreover, it is known tha...

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Detalles Bibliográficos
Autores principales:	Zhang, Jing, Liu, Jason, McGillivray, Patrick, Yi, Caroline, Lochovsky, Lucas, Lee, Donghoon, Gerstein, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580035/ https://www.ncbi.nlm.nih.gov/pubmed/33092526 http://dx.doi.org/10.1186/s12859-020-03758-1

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