Generation of Pancreatic Organoid-Derived Isografts

This protocol is a procedure for generating orthotopic isografts using mouse pancreatic cancer organoids. These isografts can be used to track the evolution of pancreatic ductal adenocarcinoma (PDA) from a preinvasive lesion to a metastatic disease and therefore represent a suitable model for identi...

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Detalles Bibliográficos
Autores principales: D’Agosto, Sabrina, Lupo, Francesca, Corbo, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580091/
https://www.ncbi.nlm.nih.gov/pubmed/33111093
http://dx.doi.org/10.1016/j.xpro.2020.100047
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author D’Agosto, Sabrina
Lupo, Francesca
Corbo, Vincenzo
author_facet D’Agosto, Sabrina
Lupo, Francesca
Corbo, Vincenzo
author_sort D’Agosto, Sabrina
collection PubMed
description This protocol is a procedure for generating orthotopic isografts using mouse pancreatic cancer organoids. These isografts can be used to track the evolution of pancreatic ductal adenocarcinoma (PDA) from a preinvasive lesion to a metastatic disease and therefore represent a suitable model for identification of determinants of PDA progression. For complete details on the use and execution of this protocol, please refer to Boj et al. (2015) and Filippini et al. (2019).
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spelling pubmed-75800912020-10-26 Generation of Pancreatic Organoid-Derived Isografts D’Agosto, Sabrina Lupo, Francesca Corbo, Vincenzo STAR Protoc Protocol This protocol is a procedure for generating orthotopic isografts using mouse pancreatic cancer organoids. These isografts can be used to track the evolution of pancreatic ductal adenocarcinoma (PDA) from a preinvasive lesion to a metastatic disease and therefore represent a suitable model for identification of determinants of PDA progression. For complete details on the use and execution of this protocol, please refer to Boj et al. (2015) and Filippini et al. (2019). Elsevier 2020-06-06 /pmc/articles/PMC7580091/ /pubmed/33111093 http://dx.doi.org/10.1016/j.xpro.2020.100047 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Protocol
D’Agosto, Sabrina
Lupo, Francesca
Corbo, Vincenzo
Generation of Pancreatic Organoid-Derived Isografts
title Generation of Pancreatic Organoid-Derived Isografts
title_full Generation of Pancreatic Organoid-Derived Isografts
title_fullStr Generation of Pancreatic Organoid-Derived Isografts
title_full_unstemmed Generation of Pancreatic Organoid-Derived Isografts
title_short Generation of Pancreatic Organoid-Derived Isografts
title_sort generation of pancreatic organoid-derived isografts
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580091/
https://www.ncbi.nlm.nih.gov/pubmed/33111093
http://dx.doi.org/10.1016/j.xpro.2020.100047
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