Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention

Increased bacterial translocation (BT) across the gut barrier due to greater intestinal permeability (IP) is seen across a range of conditions, including alcohol-related liver disease (ArLD). The phenomenon of BT may contribute to both the pathogenesis and the development of complications in ArLD. T...

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Autores principales: Skinner, Charlotte, Thompson, Alex J., Thursz, Mark R., Marchesi, Julian R., Vergis, Nikhil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Prospects and Challenges into the Role of Gut Microbiome in Health and Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580143/
https://www.ncbi.nlm.nih.gov/pubmed/33149761
http://dx.doi.org/10.1177/1756284820942616
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author Skinner, Charlotte
Thompson, Alex J.
Thursz, Mark R.
Marchesi, Julian R.
Vergis, Nikhil
author_facet Skinner, Charlotte
Thompson, Alex J.
Thursz, Mark R.
Marchesi, Julian R.
Vergis, Nikhil
author_sort Skinner, Charlotte
collection PubMed
description Increased bacterial translocation (BT) across the gut barrier due to greater intestinal permeability (IP) is seen across a range of conditions, including alcohol-related liver disease (ArLD). The phenomenon of BT may contribute to both the pathogenesis and the development of complications in ArLD. There are a number of methods available to assess IP and in this review we look at their various advantages and limitations. The knowledge around BT and IP in ArLD is also reviewed, as well as the therapeutic strategies currently in use and in development.
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spelling pubmed-75801432020-11-03 Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention Skinner, Charlotte Thompson, Alex J. Thursz, Mark R. Marchesi, Julian R. Vergis, Nikhil Therap Adv Gastroenterol Prospects and Challenges into the Role of Gut Microbiome in Health and Disease Increased bacterial translocation (BT) across the gut barrier due to greater intestinal permeability (IP) is seen across a range of conditions, including alcohol-related liver disease (ArLD). The phenomenon of BT may contribute to both the pathogenesis and the development of complications in ArLD. There are a number of methods available to assess IP and in this review we look at their various advantages and limitations. The knowledge around BT and IP in ArLD is also reviewed, as well as the therapeutic strategies currently in use and in development. SAGE Publications 2020-10-16 /pmc/articles/PMC7580143/ /pubmed/33149761 http://dx.doi.org/10.1177/1756284820942616 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Prospects and Challenges into the Role of Gut Microbiome in Health and Disease
Skinner, Charlotte
Thompson, Alex J.
Thursz, Mark R.
Marchesi, Julian R.
Vergis, Nikhil
Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention
title Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention
title_full Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention
title_fullStr Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention
title_full_unstemmed Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention
title_short Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention
title_sort intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention
topic Prospects and Challenges into the Role of Gut Microbiome in Health and Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580143/
https://www.ncbi.nlm.nih.gov/pubmed/33149761
http://dx.doi.org/10.1177/1756284820942616
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