Cargando…

Functional reconstruction of severe hand injuries using allogeneic tendons: a retrospective study

OBJECTIVE: To evaluate the effectiveness and safety of allogeneic tendons for functional reconstruction of severe hand injuries. METHODS: From August 2007 to July 2014, we performed functional reconstruction with tendon allografts for severe hand injuries affecting two or more tendons. At the final...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Gu Heng, Mao, Tian, Xing, Shu Guo, Chen, Ya Lan, Zhang, Yu Xuan, Xie, Ren Guo, Zhou, Xiao Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580153/
https://www.ncbi.nlm.nih.gov/pubmed/33059512
http://dx.doi.org/10.1177/0300060520955032
_version_ 1783598734683144192
author Wang, Gu Heng
Mao, Tian
Xing, Shu Guo
Chen, Ya Lan
Zhang, Yu Xuan
Xie, Ren Guo
Zhou, Xiao Zhong
author_facet Wang, Gu Heng
Mao, Tian
Xing, Shu Guo
Chen, Ya Lan
Zhang, Yu Xuan
Xie, Ren Guo
Zhou, Xiao Zhong
author_sort Wang, Gu Heng
collection PubMed
description OBJECTIVE: To evaluate the effectiveness and safety of allogeneic tendons for functional reconstruction of severe hand injuries. METHODS: From August 2007 to July 2014, we performed functional reconstruction with tendon allografts for severe hand injuries affecting two or more tendons. At the final follow-up, we assessed total active motion (TAM); pincer pinch strength; grip strength; Disabilities of the Arm, Shoulder, and Hand (DASH) score; degree of satisfaction; and adhesion. We measured the white blood cell count, C-reactive protein concentration, erythrocyte sedimentation rate, total T-cell count, and CD4(+)T/CD8(+)T ratio to evaluate the immune response and check for infection. RESULTS: Ten patients received 26 allogeneic tendons to reconstruct hand function. The average follow-up period was 50.0 months (range, 24–82 months). The TAM was 126.4° (12°–253°), pincer pinch strength was 0.83 kg (0–4.5 kg), and grip strength was 13.69 kg (4–41.5 kg). The DASH score was 14.25 (3.3–30.8), and seven and three patients were satisfied and partially satisfied, respectively. One patient developed tendon adhesion. All immune and infectious parameters were within the reference range. CONCLUSION: Functional reconstruction using allogeneic tendons for severe hand injuries with multiple tendon defects was effective and safe; however, more research is needed.
format Online
Article
Text
id pubmed-7580153
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-75801532020-11-03 Functional reconstruction of severe hand injuries using allogeneic tendons: a retrospective study Wang, Gu Heng Mao, Tian Xing, Shu Guo Chen, Ya Lan Zhang, Yu Xuan Xie, Ren Guo Zhou, Xiao Zhong J Int Med Res Retrospective Clinical Research Report OBJECTIVE: To evaluate the effectiveness and safety of allogeneic tendons for functional reconstruction of severe hand injuries. METHODS: From August 2007 to July 2014, we performed functional reconstruction with tendon allografts for severe hand injuries affecting two or more tendons. At the final follow-up, we assessed total active motion (TAM); pincer pinch strength; grip strength; Disabilities of the Arm, Shoulder, and Hand (DASH) score; degree of satisfaction; and adhesion. We measured the white blood cell count, C-reactive protein concentration, erythrocyte sedimentation rate, total T-cell count, and CD4(+)T/CD8(+)T ratio to evaluate the immune response and check for infection. RESULTS: Ten patients received 26 allogeneic tendons to reconstruct hand function. The average follow-up period was 50.0 months (range, 24–82 months). The TAM was 126.4° (12°–253°), pincer pinch strength was 0.83 kg (0–4.5 kg), and grip strength was 13.69 kg (4–41.5 kg). The DASH score was 14.25 (3.3–30.8), and seven and three patients were satisfied and partially satisfied, respectively. One patient developed tendon adhesion. All immune and infectious parameters were within the reference range. CONCLUSION: Functional reconstruction using allogeneic tendons for severe hand injuries with multiple tendon defects was effective and safe; however, more research is needed. SAGE Publications 2020-10-15 /pmc/articles/PMC7580153/ /pubmed/33059512 http://dx.doi.org/10.1177/0300060520955032 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Retrospective Clinical Research Report
Wang, Gu Heng
Mao, Tian
Xing, Shu Guo
Chen, Ya Lan
Zhang, Yu Xuan
Xie, Ren Guo
Zhou, Xiao Zhong
Functional reconstruction of severe hand injuries using allogeneic tendons: a retrospective study
title Functional reconstruction of severe hand injuries using allogeneic tendons: a retrospective study
title_full Functional reconstruction of severe hand injuries using allogeneic tendons: a retrospective study
title_fullStr Functional reconstruction of severe hand injuries using allogeneic tendons: a retrospective study
title_full_unstemmed Functional reconstruction of severe hand injuries using allogeneic tendons: a retrospective study
title_short Functional reconstruction of severe hand injuries using allogeneic tendons: a retrospective study
title_sort functional reconstruction of severe hand injuries using allogeneic tendons: a retrospective study
topic Retrospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580153/
https://www.ncbi.nlm.nih.gov/pubmed/33059512
http://dx.doi.org/10.1177/0300060520955032
work_keys_str_mv AT wangguheng functionalreconstructionofseverehandinjuriesusingallogeneictendonsaretrospectivestudy
AT maotian functionalreconstructionofseverehandinjuriesusingallogeneictendonsaretrospectivestudy
AT xingshuguo functionalreconstructionofseverehandinjuriesusingallogeneictendonsaretrospectivestudy
AT chenyalan functionalreconstructionofseverehandinjuriesusingallogeneictendonsaretrospectivestudy
AT zhangyuxuan functionalreconstructionofseverehandinjuriesusingallogeneictendonsaretrospectivestudy
AT xierenguo functionalreconstructionofseverehandinjuriesusingallogeneictendonsaretrospectivestudy
AT zhouxiaozhong functionalreconstructionofseverehandinjuriesusingallogeneictendonsaretrospectivestudy