X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure

We previously reported the Bruton's tyrosine kinase (BTK) inhibitors ibrutinib and acalabrutinib improve outcomes in a mouse model of polymicrobial sepsis. Now we show that genetic deficiency of the BTK gene alone in Xid mice confers protection against cardiac, renal, and liver injury in polymi...

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Detalles Bibliográficos
Autores principales: O'Riordan, Caroline E., Purvis, Gareth S. D., Collotta, Debora, Krieg, Nadine, Wissuwa, Bianka, Sheikh, Madeeha H., Ferreira Alves, Gustavo, Mohammad, Shireen, Callender, Lauren A., Coldewey, Sina M., Collino, Massimo, Greaves, David R., Thiemermann, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580254/
https://www.ncbi.nlm.nih.gov/pubmed/33162995
http://dx.doi.org/10.3389/fimmu.2020.581758

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