Innate and adaptive immune responses against coronavirus

Coronaviruses (CoVs) are a member of the Coronaviridae family with positive‐sense single- stranded RNA. In recent years, the CoVs have become a global problem to public health. The immune responses (innate and adaptive immunity) are essential for elimination and clearance of CoVs infections, however...

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Detalles Bibliográficos
Autores principales: Hosseini, Arezoo, Hashemi, Vida, Shomali, Navid, Asghari, Faezeh, Gharibi, Tohid, Akbari, Morteza, Gholizadeh, Saber, Jafari, Abbas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Masson SAS. 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580677/
https://www.ncbi.nlm.nih.gov/pubmed/33120236
http://dx.doi.org/10.1016/j.biopha.2020.110859
Descripción
Sumario:Coronaviruses (CoVs) are a member of the Coronaviridae family with positive‐sense single- stranded RNA. In recent years, the CoVs have become a global problem to public health. The immune responses (innate and adaptive immunity) are essential for elimination and clearance of CoVs infections, however, uncontrolled immune responses can result in aggravating acute lung injury and significant immunopathology. Gaining profound understanding about the interaction between CoVs and the innate and adaptive immune systems could be a critical step in the field of treatment. In this review, we present an update on the host innate and adaptive immune responses against SARS-CoV, MERS-CoV and newly appeared SARS-CoV-2.

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