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Positive selection in admixed populations from Ethiopia
BACKGROUND: In the process of adaptation of humans to their environment, positive or adaptive selection has played a main role. Positive selection has, however, been under-studied in African populations, despite their diversity and importance for understanding human history. RESULTS: Here, we have u...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580818/ https://www.ncbi.nlm.nih.gov/pubmed/33092534 http://dx.doi.org/10.1186/s12863-020-00908-5 |
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author | Walsh, Sandra Pagani, Luca Xue, Yali Laayouni, Hafid Tyler-Smith, Chris Bertranpetit, Jaume |
author_facet | Walsh, Sandra Pagani, Luca Xue, Yali Laayouni, Hafid Tyler-Smith, Chris Bertranpetit, Jaume |
author_sort | Walsh, Sandra |
collection | PubMed |
description | BACKGROUND: In the process of adaptation of humans to their environment, positive or adaptive selection has played a main role. Positive selection has, however, been under-studied in African populations, despite their diversity and importance for understanding human history. RESULTS: Here, we have used 119 available whole-genome sequences from five Ethiopian populations (Amhara, Oromo, Somali, Wolayta and Gumuz) to investigate the modes and targets of positive selection in this part of the world. The site frequency spectrum-based test SFselect was applied to idfentify a wide range of events of selection (old and recent), and the haplotype-based statistic integrated haplotype score to detect more recent events, in each case with evaluation of the significance of candidate signals by extensive simulations. Additional insights were provided by considering admixture proportions and functional categories of genes. We identified both individual loci that are likely targets of classic sweeps and groups of genes that may have experienced polygenic adaptation. We found population-specific as well as shared signals of selection, with folate metabolism and the related ultraviolet response and skin pigmentation standing out as a shared pathway, perhaps as a response to the high levels of ultraviolet irradiation, and in addition strong signals in genes such as IFNA, MRC1, immunoglobulins and T-cell receptors which contribute to defend against pathogens. CONCLUSIONS: Signals of positive selection were detected in Ethiopian populations revealing novel adaptations in East Africa, and abundant targets for functional follow-up. |
format | Online Article Text |
id | pubmed-7580818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-75808182020-10-23 Positive selection in admixed populations from Ethiopia Walsh, Sandra Pagani, Luca Xue, Yali Laayouni, Hafid Tyler-Smith, Chris Bertranpetit, Jaume BMC Genet Research BACKGROUND: In the process of adaptation of humans to their environment, positive or adaptive selection has played a main role. Positive selection has, however, been under-studied in African populations, despite their diversity and importance for understanding human history. RESULTS: Here, we have used 119 available whole-genome sequences from five Ethiopian populations (Amhara, Oromo, Somali, Wolayta and Gumuz) to investigate the modes and targets of positive selection in this part of the world. The site frequency spectrum-based test SFselect was applied to idfentify a wide range of events of selection (old and recent), and the haplotype-based statistic integrated haplotype score to detect more recent events, in each case with evaluation of the significance of candidate signals by extensive simulations. Additional insights were provided by considering admixture proportions and functional categories of genes. We identified both individual loci that are likely targets of classic sweeps and groups of genes that may have experienced polygenic adaptation. We found population-specific as well as shared signals of selection, with folate metabolism and the related ultraviolet response and skin pigmentation standing out as a shared pathway, perhaps as a response to the high levels of ultraviolet irradiation, and in addition strong signals in genes such as IFNA, MRC1, immunoglobulins and T-cell receptors which contribute to defend against pathogens. CONCLUSIONS: Signals of positive selection were detected in Ethiopian populations revealing novel adaptations in East Africa, and abundant targets for functional follow-up. BioMed Central 2020-10-22 /pmc/articles/PMC7580818/ /pubmed/33092534 http://dx.doi.org/10.1186/s12863-020-00908-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Walsh, Sandra Pagani, Luca Xue, Yali Laayouni, Hafid Tyler-Smith, Chris Bertranpetit, Jaume Positive selection in admixed populations from Ethiopia |
title | Positive selection in admixed populations from Ethiopia |
title_full | Positive selection in admixed populations from Ethiopia |
title_fullStr | Positive selection in admixed populations from Ethiopia |
title_full_unstemmed | Positive selection in admixed populations from Ethiopia |
title_short | Positive selection in admixed populations from Ethiopia |
title_sort | positive selection in admixed populations from ethiopia |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580818/ https://www.ncbi.nlm.nih.gov/pubmed/33092534 http://dx.doi.org/10.1186/s12863-020-00908-5 |
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