Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis

The liver is a central regulator of metabolic homeostasis and serum metabolite levels. Hepatocytes are the functional units of the liver parenchyma and not only responsible for turnover of biomolecules but also act as central immune signaling platforms. Hepatotropic viruses infect liver tissue, resu...

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Detalles Bibliográficos
Autores principales: Lercher, Alexander, Popa, Alexandra M., Viczenczova, Csilla, Kosack, Lindsay, Klavins, Kristaps, Agerer, Benedikt, Opitz, Christiane A., Lanz, Tobias V., Platten, Michael, Bergthaler, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580883/
https://www.ncbi.nlm.nih.gov/pubmed/33045014
http://dx.doi.org/10.1371/journal.ppat.1008973

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