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Severe asthma is associated with a remodeling of the pulmonary arteries in horses

Pulmonary hypertension and cor pulmonale are complications of severe equine asthma, as a consequence of pulmonary hypoxic vasoconstriction. However, as pulmonary hypertension is only partially reversible by oxygen administration, other etiological factors are likely involved. In human chronic obstru...

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Autores principales: Ceriotti, Serena, Bullone, Michela, Leclere, Mathilde, Ferrucci, Francesco, Lavoie, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580920/
https://www.ncbi.nlm.nih.gov/pubmed/33091038
http://dx.doi.org/10.1371/journal.pone.0239561
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author Ceriotti, Serena
Bullone, Michela
Leclere, Mathilde
Ferrucci, Francesco
Lavoie, Jean-Pierre
author_facet Ceriotti, Serena
Bullone, Michela
Leclere, Mathilde
Ferrucci, Francesco
Lavoie, Jean-Pierre
author_sort Ceriotti, Serena
collection PubMed
description Pulmonary hypertension and cor pulmonale are complications of severe equine asthma, as a consequence of pulmonary hypoxic vasoconstriction. However, as pulmonary hypertension is only partially reversible by oxygen administration, other etiological factors are likely involved. In human chronic obstructive pulmonary disease, pulmonary artery remodeling contributes to the development of pulmonary hypertension. In rodent models, pulmonary vascular remodeling is present as a consequence of allergic airway inflammation. The present study investigated the presence of remodeling of the pulmonary arteries in severe equine asthma, its distribution throughout the lungs, and its reversibility following long-term antigen avoidance strategies and inhaled corticosteroid administration. Using histomorphometry, the total wall area of pulmonary arteries from different regions of the lungs of asthmatic horses and controls was measured. The smooth muscle mass of pulmonary arteries was also estimated on lung sections stained for α-smooth muscle actin. Reversibility of vascular changes in asthmatic horses was assessed after 1 year of antigen avoidance alone or treatment with inhaled fluticasone. Pulmonary arteries showed increased wall area in apical and caudodorsal lung regions of asthmatic horses in both exacerbation and remission. The pulmonary arteries smooth muscle mass was similarly increased. Both treatments reversed the increase in wall area. However, a trend for normalization of the vascular smooth muscle mass was observed only after treatment with antigen avoidance, but not with fluticasone. In conclusion, severe equine asthma is associated with remodeling of the pulmonary arteries consisting in an increased smooth muscle mass. The resulting narrowing of the artery lumen could enhance hypoxic vasoconstriction, contributing to pulmonary hypertension. In our study population, the antigen avoidance strategy appeared more promising than inhaled corticosteroids in controlling vascular remodeling. However, further studies are needed to support the reversibility of vascular smooth muscle mass remodeling after asthma treatment.
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spelling pubmed-75809202020-10-27 Severe asthma is associated with a remodeling of the pulmonary arteries in horses Ceriotti, Serena Bullone, Michela Leclere, Mathilde Ferrucci, Francesco Lavoie, Jean-Pierre PLoS One Research Article Pulmonary hypertension and cor pulmonale are complications of severe equine asthma, as a consequence of pulmonary hypoxic vasoconstriction. However, as pulmonary hypertension is only partially reversible by oxygen administration, other etiological factors are likely involved. In human chronic obstructive pulmonary disease, pulmonary artery remodeling contributes to the development of pulmonary hypertension. In rodent models, pulmonary vascular remodeling is present as a consequence of allergic airway inflammation. The present study investigated the presence of remodeling of the pulmonary arteries in severe equine asthma, its distribution throughout the lungs, and its reversibility following long-term antigen avoidance strategies and inhaled corticosteroid administration. Using histomorphometry, the total wall area of pulmonary arteries from different regions of the lungs of asthmatic horses and controls was measured. The smooth muscle mass of pulmonary arteries was also estimated on lung sections stained for α-smooth muscle actin. Reversibility of vascular changes in asthmatic horses was assessed after 1 year of antigen avoidance alone or treatment with inhaled fluticasone. Pulmonary arteries showed increased wall area in apical and caudodorsal lung regions of asthmatic horses in both exacerbation and remission. The pulmonary arteries smooth muscle mass was similarly increased. Both treatments reversed the increase in wall area. However, a trend for normalization of the vascular smooth muscle mass was observed only after treatment with antigen avoidance, but not with fluticasone. In conclusion, severe equine asthma is associated with remodeling of the pulmonary arteries consisting in an increased smooth muscle mass. The resulting narrowing of the artery lumen could enhance hypoxic vasoconstriction, contributing to pulmonary hypertension. In our study population, the antigen avoidance strategy appeared more promising than inhaled corticosteroids in controlling vascular remodeling. However, further studies are needed to support the reversibility of vascular smooth muscle mass remodeling after asthma treatment. Public Library of Science 2020-10-22 /pmc/articles/PMC7580920/ /pubmed/33091038 http://dx.doi.org/10.1371/journal.pone.0239561 Text en © 2020 Ceriotti et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ceriotti, Serena
Bullone, Michela
Leclere, Mathilde
Ferrucci, Francesco
Lavoie, Jean-Pierre
Severe asthma is associated with a remodeling of the pulmonary arteries in horses
title Severe asthma is associated with a remodeling of the pulmonary arteries in horses
title_full Severe asthma is associated with a remodeling of the pulmonary arteries in horses
title_fullStr Severe asthma is associated with a remodeling of the pulmonary arteries in horses
title_full_unstemmed Severe asthma is associated with a remodeling of the pulmonary arteries in horses
title_short Severe asthma is associated with a remodeling of the pulmonary arteries in horses
title_sort severe asthma is associated with a remodeling of the pulmonary arteries in horses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580920/
https://www.ncbi.nlm.nih.gov/pubmed/33091038
http://dx.doi.org/10.1371/journal.pone.0239561
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