A Human IRE1 Inhibitor Blocks the Unfolded Protein Response in the Pathogenic Fungus Aspergillus fumigatus and Suggests Noncanonical Functions within the Pathway

The unfolded protein response (UPR) is a signaling network that maintains homeostasis of the endoplasmic reticulum (ER). In the human-pathogenic fungus Aspergillus fumigatus, the UPR is initiated by activation of an endoribonuclease (RNase) domain in the ER transmembrane stress sensor IreA, which sp...

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Detalles Bibliográficos
Autores principales: Guirao-Abad, José P., Weichert, Martin, Albee, Aaron, Deck, Katie, Askew, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580959/
https://www.ncbi.nlm.nih.gov/pubmed/33087521
http://dx.doi.org/10.1128/mSphere.00879-20

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