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Pharmacological evidence for the implication of noradrenaline in effort
The trade-off between effort and reward is one of the main determinants of behavior, and its alteration is at the heart of major disorders such as depression or Parkinson’s disease. Monoaminergic neuromodulators are thought to play a key role in this trade-off, but their relative contribution remain...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580990/ https://www.ncbi.nlm.nih.gov/pubmed/33044952 http://dx.doi.org/10.1371/journal.pbio.3000793 |
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author | Borderies, Nicolas Bornert, Pauline Gilardeau, Sophie Bouret, Sebastien |
author_facet | Borderies, Nicolas Bornert, Pauline Gilardeau, Sophie Bouret, Sebastien |
author_sort | Borderies, Nicolas |
collection | PubMed |
description | The trade-off between effort and reward is one of the main determinants of behavior, and its alteration is at the heart of major disorders such as depression or Parkinson’s disease. Monoaminergic neuromodulators are thought to play a key role in this trade-off, but their relative contribution remains unclear. Rhesus monkeys (Macaca mulatta) performed a choice task requiring a trade-off between the volume of fluid reward and the amount of force to be exerted on a grip. In line with a causal role of noradrenaline in effort, decreasing noradrenaline levels with systemic clonidine injections (0.01 mg/kg) decreased exerted force and enhanced the weight of upcoming force on choices, without any effect on reward sensitivity. Using computational modeling, we showed that a single variable (“effort”) could capture the amount of resources necessary for action and control both choices (as a variable for decision) and force production (as a driving force). Critically, the multiple effects of noradrenaline manipulation on behavior could be captured by a specific modulation of this single variable. Thus, our data strongly support noradrenaline’s implication in effort processing. |
format | Online Article Text |
id | pubmed-7580990 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-75809902020-10-27 Pharmacological evidence for the implication of noradrenaline in effort Borderies, Nicolas Bornert, Pauline Gilardeau, Sophie Bouret, Sebastien PLoS Biol Research Article The trade-off between effort and reward is one of the main determinants of behavior, and its alteration is at the heart of major disorders such as depression or Parkinson’s disease. Monoaminergic neuromodulators are thought to play a key role in this trade-off, but their relative contribution remains unclear. Rhesus monkeys (Macaca mulatta) performed a choice task requiring a trade-off between the volume of fluid reward and the amount of force to be exerted on a grip. In line with a causal role of noradrenaline in effort, decreasing noradrenaline levels with systemic clonidine injections (0.01 mg/kg) decreased exerted force and enhanced the weight of upcoming force on choices, without any effect on reward sensitivity. Using computational modeling, we showed that a single variable (“effort”) could capture the amount of resources necessary for action and control both choices (as a variable for decision) and force production (as a driving force). Critically, the multiple effects of noradrenaline manipulation on behavior could be captured by a specific modulation of this single variable. Thus, our data strongly support noradrenaline’s implication in effort processing. Public Library of Science 2020-10-12 /pmc/articles/PMC7580990/ /pubmed/33044952 http://dx.doi.org/10.1371/journal.pbio.3000793 Text en © 2020 Borderies et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Borderies, Nicolas Bornert, Pauline Gilardeau, Sophie Bouret, Sebastien Pharmacological evidence for the implication of noradrenaline in effort |
title | Pharmacological evidence for the implication of noradrenaline in effort |
title_full | Pharmacological evidence for the implication of noradrenaline in effort |
title_fullStr | Pharmacological evidence for the implication of noradrenaline in effort |
title_full_unstemmed | Pharmacological evidence for the implication of noradrenaline in effort |
title_short | Pharmacological evidence for the implication of noradrenaline in effort |
title_sort | pharmacological evidence for the implication of noradrenaline in effort |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580990/ https://www.ncbi.nlm.nih.gov/pubmed/33044952 http://dx.doi.org/10.1371/journal.pbio.3000793 |
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