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The epidemiological characteristics and profile of drug-resistant tuberculosis among children with tuberculosis in Sichuan, China, 2015–2018: A retrospective study

The aim of this study was to investigate the epidemiological characteristics and profile of drug-resistant tuberculosis (DR-TB) among children with TB in Sichuan province of China. From January 2015 to December 2018, microbiological culture-confirmed child TB cases (aged <15 years old) were enrol...

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Autores principales: Xu, Yuanhong, Li, Qingfeng, Zhu, Ma, Wu, Xueqi, Wang, Dongmei, Luo, Jia, Li, Yingjie, Zhong, Jing, Zeng, Peibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581151/
https://www.ncbi.nlm.nih.gov/pubmed/33120748
http://dx.doi.org/10.1097/MD.0000000000022608
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author Xu, Yuanhong
Li, Qingfeng
Zhu, Ma
Wu, Xueqi
Wang, Dongmei
Luo, Jia
Li, Yingjie
Zhong, Jing
Zeng, Peibin
author_facet Xu, Yuanhong
Li, Qingfeng
Zhu, Ma
Wu, Xueqi
Wang, Dongmei
Luo, Jia
Li, Yingjie
Zhong, Jing
Zeng, Peibin
author_sort Xu, Yuanhong
collection PubMed
description The aim of this study was to investigate the epidemiological characteristics and profile of drug-resistant tuberculosis (DR-TB) among children with TB in Sichuan province of China. From January 2015 to December 2018, microbiological culture-confirmed child TB cases (aged <15 years old) were enrolled retrospectively. Epidemiological and clinical information from these cases, and the drug susceptibility testing results of the isolates were collected and analyzed. Of 317 culture-confirmed child TB cases, 16.7% (53/317) were aged under 5 years old. 54.9% were Tibetans, and 31.9% had clear history of contact with TB patients. More than half (53.9%) were not vaccinated by Calmette–Guérin bacillus (BCG). Thirty percent (n = 95) were diagnosed as severe TB, and 92.4% (n = 293) were new cases. The ratio of severe TB in BCG vaccinated group was significant lower than that observed in unvaccinated group (P < .01). Significantly higher proportion of severe TB among Tibetans than Han child TB cases was observed in BCG unvaccinated group (P < .01). The overall rate of DR-TB in this study was 24.3% (77/317) and 17 multidrug-resistant tuberculosis (MDR-TB) cases were identified with rate of MDR-TB at 5.4% (17/317). No extensively drug-resistant case was found. Thirteen out of 17 MDR-TB cases (76.4%) were Tibetan children. The ratio of any resistance to 4 first-line drugs identified were: isoniazid (INH), 15.5%; rifampicin (RIF), 9.1%; ethambutol, 0.6% and streptomycin, 6.0%, respectively. More than half of MDR patterns were resistant to INH + RIF (9/17), followed by at least resistance to INH + RIF + streptomycin (n = 7). This was the first investigation on the epidemiological characteristics and profiles of DR-TB among child TB cases in Southwest of China. Our findings indicated a potentially high risk of TB infection to Tibetan children in the concentrated Tibetan communities of Sichuan.
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spelling pubmed-75811512020-10-30 The epidemiological characteristics and profile of drug-resistant tuberculosis among children with tuberculosis in Sichuan, China, 2015–2018: A retrospective study Xu, Yuanhong Li, Qingfeng Zhu, Ma Wu, Xueqi Wang, Dongmei Luo, Jia Li, Yingjie Zhong, Jing Zeng, Peibin Medicine (Baltimore) 4900 The aim of this study was to investigate the epidemiological characteristics and profile of drug-resistant tuberculosis (DR-TB) among children with TB in Sichuan province of China. From January 2015 to December 2018, microbiological culture-confirmed child TB cases (aged <15 years old) were enrolled retrospectively. Epidemiological and clinical information from these cases, and the drug susceptibility testing results of the isolates were collected and analyzed. Of 317 culture-confirmed child TB cases, 16.7% (53/317) were aged under 5 years old. 54.9% were Tibetans, and 31.9% had clear history of contact with TB patients. More than half (53.9%) were not vaccinated by Calmette–Guérin bacillus (BCG). Thirty percent (n = 95) were diagnosed as severe TB, and 92.4% (n = 293) were new cases. The ratio of severe TB in BCG vaccinated group was significant lower than that observed in unvaccinated group (P < .01). Significantly higher proportion of severe TB among Tibetans than Han child TB cases was observed in BCG unvaccinated group (P < .01). The overall rate of DR-TB in this study was 24.3% (77/317) and 17 multidrug-resistant tuberculosis (MDR-TB) cases were identified with rate of MDR-TB at 5.4% (17/317). No extensively drug-resistant case was found. Thirteen out of 17 MDR-TB cases (76.4%) were Tibetan children. The ratio of any resistance to 4 first-line drugs identified were: isoniazid (INH), 15.5%; rifampicin (RIF), 9.1%; ethambutol, 0.6% and streptomycin, 6.0%, respectively. More than half of MDR patterns were resistant to INH + RIF (9/17), followed by at least resistance to INH + RIF + streptomycin (n = 7). This was the first investigation on the epidemiological characteristics and profiles of DR-TB among child TB cases in Southwest of China. Our findings indicated a potentially high risk of TB infection to Tibetan children in the concentrated Tibetan communities of Sichuan. Lippincott Williams & Wilkins 2020-10-23 /pmc/articles/PMC7581151/ /pubmed/33120748 http://dx.doi.org/10.1097/MD.0000000000022608 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 4900
Xu, Yuanhong
Li, Qingfeng
Zhu, Ma
Wu, Xueqi
Wang, Dongmei
Luo, Jia
Li, Yingjie
Zhong, Jing
Zeng, Peibin
The epidemiological characteristics and profile of drug-resistant tuberculosis among children with tuberculosis in Sichuan, China, 2015–2018: A retrospective study
title The epidemiological characteristics and profile of drug-resistant tuberculosis among children with tuberculosis in Sichuan, China, 2015–2018: A retrospective study
title_full The epidemiological characteristics and profile of drug-resistant tuberculosis among children with tuberculosis in Sichuan, China, 2015–2018: A retrospective study
title_fullStr The epidemiological characteristics and profile of drug-resistant tuberculosis among children with tuberculosis in Sichuan, China, 2015–2018: A retrospective study
title_full_unstemmed The epidemiological characteristics and profile of drug-resistant tuberculosis among children with tuberculosis in Sichuan, China, 2015–2018: A retrospective study
title_short The epidemiological characteristics and profile of drug-resistant tuberculosis among children with tuberculosis in Sichuan, China, 2015–2018: A retrospective study
title_sort epidemiological characteristics and profile of drug-resistant tuberculosis among children with tuberculosis in sichuan, china, 2015–2018: a retrospective study
topic 4900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581151/
https://www.ncbi.nlm.nih.gov/pubmed/33120748
http://dx.doi.org/10.1097/MD.0000000000022608
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