Cargando…

BCL11B suppresses tumor progression and stem cell traits in hepatocellular carcinoma by restoring p53 signaling activity

Accumulating evidence indicates that hepatocellular carcinoma (HCC) tumorigenesis, recurrence, metastasis, and therapeutic resistance are strongly associated with liver cancer stem cells (CSCs), a rare subpopulation of highly tumorigenic cells with self-renewal capacity and differentiation potential...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Wen-Jing, Sun, Yun-Fan, Jin, An-Li, Lv, Li-Hua, Zhu, Jie, Wang, Bei-Li, Zhou, Yan, Zhang, Chun-Yan, Wang, Hao, Hu, Bo, Wang, Peng-Xiang, Te, Liu, Pan, Bai-Shen, Zhou, Jian, Fan, Jia, Yang, Xin-Rong, Guo, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581528/ https://www.ncbi.nlm.nih.gov/pubmed/33093445 http://dx.doi.org/10.1038/s41419-020-03115-3

Ejemplares similares

Bcl11a is essential for lymphoid development and negatively regulates p53
por: Yu, Yong, et al.
Publicado: (2012)

SERPINA11 Inhibits Metastasis in Hepatocellular Carcinoma by Suppressing MEK/ERK Signaling Pathway
por: Song, Ye, et al.
Publicado: (2021)

BCL7C suppresses ovarian cancer growth by inactivating mutant p53
por: Huang, Canhua, et al.
Publicado: (2020)

Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity
por: Wei, Hudie, et al.
Publicado: (2023)

Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells
por: Chen, Haibo, et al.
Publicado: (2017)

Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling
por: Cao, Pengbo, et al.
Publicado: (2021)

Exosomal microRNAs in the DLK1-DIO3 imprinted region derived from cancer-associated fibroblasts promote progression of hepatocellular carcinoma by targeting hedgehog interacting protein
por: Jin, An-Li, et al.
Publicado: (2022)

LIN28B inhibition sensitizes cells to p53-restoring PPI therapy through unleashed translational suppression
por: Shi, Jiahao, et al.
Publicado: (2022)

High serum soluble CD155 level predicts poor prognosis and correlates with an immunosuppressive tumor microenvironment in hepatocellular carcinoma
por: Jin, An‐Li, et al.
Publicado: (2022)

Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas
por: Pinkney, Kerice A., et al.
Publicado: (2015)

Comprehensive Analysis of HHLA2 as a Prognostic Biomarker and Its Association With Immune Infiltrates in Hepatocellular Carcinoma
por: Ding, Lin, et al.
Publicado: (2022)

MYC/BCL2/BCL6 triple hit and TP53 deletion in a case of high-grade B cell lymphoma receiving CAR T cell immunotherapy
por: Wang, Jiachen, et al.
Publicado: (2021)

Novel hybrid molecule overcomes the limited response of solid tumours to HDAC inhibitors via suppressing JAK1-STAT3-BCL2 signalling
por: Huang, Zhi, et al.
Publicado: (2018)

CD73 promotes hepatocellular carcinoma progression and metastasis via activating PI3K/AKT signaling by inducing Rap1-mediated membrane localization of P110β and predicts poor prognosis
por: Ma, Xiao-Lu, et al.
Publicado: (2019)

Proteinase-activated receptor-2 enhances Bcl2-like protein-12 expression in lung cancer cells to suppress p53 expression
por: Ma, Guoyuan, et al.
Publicado: (2019)

The tissue dependent interactions between p53 and Bcl-2 in vivo
por: Li, Xin, et al.
Publicado: (2015)

Bcl-xL Reduces Chinese Giant Salamander Iridovirus-Induced Mitochondrial Apoptosis by Interacting with Bak and Inhibiting the p53 Pathway
por: Li, Yiqun, et al.
Publicado: (2021)

CD155/SRC complex promotes hepatocellular carcinoma progression via inhibiting the p38 MAPK signalling pathway and correlates with poor prognosis
por: Jin, An‐Li, et al.
Publicado: (2022)

Hypoxia blocks ferroptosis of hepatocellular carcinoma via suppression of METTL14 triggered YTHDF2‐dependent silencing of SLC7A11
por: Fan, Zhuoyang, et al.
Publicado: (2021)

Homoharringtonine suppresses imatinib resistance via the Bcl-6/p53 pathway in chronic myeloid leukemia cell lines
por: Wang, Qian, et al.
Publicado: (2017)

BCL11A Promotes the Progression of Laryngeal Squamous Cell Carcinoma
por: Zhou, Jian, et al.
Publicado: (2020)

A novel variant in BCL11B in an individual with neurodevelopmental delay: A case report
por: Yu, Yonglin, et al.
Publicado: (2023)

High Expression of BCL11A Predicts Poor Prognosis for Childhood MLL-r ALL
por: Wang, Lu-Lu, et al.
Publicado: (2021)

FCN3 inhibits the progression of hepatocellular carcinoma by suppressing SBDS-mediated blockade of the p53 pathway
por: Ma, Dong, et al.
Publicado: (2023)

Bcl6 Preserves the Suppressive Function of Regulatory T Cells During Tumorigenesis
por: Li, Yiding, et al.
Publicado: (2020)

BCL11B expression in hepatocellular carcinoma relates to chemosensitivity and clinical prognosis
por: Abe, Hiroyuki, et al.
Publicado: (2023)

Development and validation of a TP53-associated immune prognostic model for hepatocellular carcinoma
por: Long, Junyu, et al.
Publicado: (2019)

BCL6B expression in hepatocellular carcinoma and its efficacy in the inhibition of liver damage and fibrogenesis
por: Wang, Weilin, et al.
Publicado: (2015)

miR-202 Suppresses Hepatocellular Carcinoma Progression via Downregulating BCL2 Expression
por: Zhuang, Donghai, et al.
Publicado: (2020)

Genetic polymorphisms and plasma levels of BCL11A contribute to the development of laryngeal squamous cell carcinoma
por: Zhou, Jian, et al.
Publicado: (2017)

Chidamide induces apoptosis in DLBCL cells by suppressing the HDACs/STAT3/Bcl-2 pathway
por: Zhang, Hongwei, et al.
Publicado: (2021)

New potential instrument to fight hepatocellular cancer by restoring p53
por: Vincent, Franklin C., et al.
Publicado: (2011)

The role of BCL11B in hematological malignancy
por: Huang, Xin, et al.
Publicado: (2012)

Transforming growth factor-beta1 suppresses hepatocellular carcinoma proliferation via activation of Hippo signaling
por: Zhang, Xiaodong, et al.
Publicado: (2017)

Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer
por: Zhang, Haiyang, et al.
Publicado: (2016)

CD24–p53 axis suppresses diethylnitrosamine-induced hepatocellular carcinogenesis by sustaining intrahepatic macrophages
por: Li, Dongling, et al.
Publicado: (2018)

Significance of PIVKA-II levels for predicting microvascular invasion and tumor cell proliferation in Chinese patients with hepatitis B virus-associated hepatocellular carcinoma
por: Ma, Xiao-Lu, et al.
Publicado: (2018)

Resveratrol suppresses human cervical carcinoma cell proliferation and elevates apoptosis via the mitochondrial and p53 signaling pathways
por: Li, Lin, et al.
Publicado: (2018)

Depletion of DNMT3A Suppressed Cell Proliferation and Restored PTEN in Hepatocellular Carcinoma Cell
por: Zhao, Zhujiang, et al.
Publicado: (2010)

Mutant BCL11B in a Patient With a Neurodevelopmental Disorder and T-Cell Abnormalities
por: Yang, Sai, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_jb2q35ff98lcfsr9d9qusrtlam