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Single-Shot Ad26 Vaccine Protects Against SARS-CoV-2 in Rhesus Macaques
A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be required to end the coronavirus disease 2019 (COVID-19) pandemic(1–8). For global deployment and pandemic control, a vaccine that requires only a single immunization would be optimal. Here we show th...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581548/ https://www.ncbi.nlm.nih.gov/pubmed/32731257 http://dx.doi.org/10.1038/s41586-020-2607-z |
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| author | Mercado, Noe B. Zahn, Roland Wegmann, Frank Loos, Carolin Chandrashekar, Abishek Yu, Jingyou Liu, Jinyan Peter, Lauren McMahan, Katherine Tostanoski, Lisa H. He, Xuan Martinez, David R. Rutten, Lucy Bos, Rinke van Manen, Danielle Vellinga, Jort Custers, Jerome Langedijk, Johannes P. Kwaks, Ted Bakkers, Mark J.G. Zuijdgeest, David Huber, Sietske K. Rosendahl Atyeo, Caroline Fischinger, Stephanie Burke, John S. Feldman, Jared Hauser, Blake M. Caradonna, Timothy M. Bondzie, Esther A. Dagotto, Gabriel Gebre, Makda S. Hoffman, Emily Jacob-Dolan, Catherine Kirilova, Marinela Li, Zhenfeng Lin, Zijin Mahrokhian, Shant H. Maxfield, Lori F. Nampanya, Felix Nityanandam, Ramya Nkolola, Joseph P. Patel, Shivani Ventura, John D. Verrington, Kaylee Wan, Huahua Pessaint, Laurent Van Ry, Alex Blade, Kelvin Strasbaugh, Amanda Cabus, Mehtap Brown, Renita Cook, Anthony Zouantchangadou, Serge Teow, Elyse Andersen, Hanne Lewis, Mark G. Cai, Yongfei Chen, Bing Schmidt, Aaron G. Reeves, R. Keith Baric, Ralph S. Lauffenburger, Douglas A. Alter, Galit Stoffels, Paul Mammen, Mathai Van Hoof, Johan Schuitemaker, Hanneke Barouch, Dan H. |
| author_facet | Mercado, Noe B. Zahn, Roland Wegmann, Frank Loos, Carolin Chandrashekar, Abishek Yu, Jingyou Liu, Jinyan Peter, Lauren McMahan, Katherine Tostanoski, Lisa H. He, Xuan Martinez, David R. Rutten, Lucy Bos, Rinke van Manen, Danielle Vellinga, Jort Custers, Jerome Langedijk, Johannes P. Kwaks, Ted Bakkers, Mark J.G. Zuijdgeest, David Huber, Sietske K. Rosendahl Atyeo, Caroline Fischinger, Stephanie Burke, John S. Feldman, Jared Hauser, Blake M. Caradonna, Timothy M. Bondzie, Esther A. Dagotto, Gabriel Gebre, Makda S. Hoffman, Emily Jacob-Dolan, Catherine Kirilova, Marinela Li, Zhenfeng Lin, Zijin Mahrokhian, Shant H. Maxfield, Lori F. Nampanya, Felix Nityanandam, Ramya Nkolola, Joseph P. Patel, Shivani Ventura, John D. Verrington, Kaylee Wan, Huahua Pessaint, Laurent Van Ry, Alex Blade, Kelvin Strasbaugh, Amanda Cabus, Mehtap Brown, Renita Cook, Anthony Zouantchangadou, Serge Teow, Elyse Andersen, Hanne Lewis, Mark G. Cai, Yongfei Chen, Bing Schmidt, Aaron G. Reeves, R. Keith Baric, Ralph S. Lauffenburger, Douglas A. Alter, Galit Stoffels, Paul Mammen, Mathai Van Hoof, Johan Schuitemaker, Hanneke Barouch, Dan H. |
| author_sort | Mercado, Noe B. |
| collection | PubMed |
| description | A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be required to end the coronavirus disease 2019 (COVID-19) pandemic(1–8). For global deployment and pandemic control, a vaccine that requires only a single immunization would be optimal. Here we show the immunogenicity and protective efficacy of a single dose of adenovirus serotype 26 (Ad26) vector-based vaccines expressing the SARS-CoV-2 spike (S) protein in nonhuman primates. 52 rhesus macaques were immunized with Ad26 vectors encoding S variants or sham control and were challenged with SARS-CoV-2 by the intranasal and intratracheal routes(9,10). The optimal Ad26 vaccine induced robust neutralizing antibody responses and provided complete or near-complete protection in bronchoalveolar lavage and nasal swabs following SARS-CoV-2 challenge. Vaccine-elicited neutralizing antibody titers correlated with protective efficacy, suggesting an immune correlate of protection. These data demonstrate robust single-shot vaccine protection against SARS-CoV-2 in nonhuman primates. The optimal Ad26 vector-based vaccine for SARS-CoV-2, termed Ad26.COV2.S, is currently being evaluated in clinical trials. |
| format | Online Article Text |
| id | pubmed-7581548 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-75815482021-01-30 Single-Shot Ad26 Vaccine Protects Against SARS-CoV-2 in Rhesus Macaques Mercado, Noe B. Zahn, Roland Wegmann, Frank Loos, Carolin Chandrashekar, Abishek Yu, Jingyou Liu, Jinyan Peter, Lauren McMahan, Katherine Tostanoski, Lisa H. He, Xuan Martinez, David R. Rutten, Lucy Bos, Rinke van Manen, Danielle Vellinga, Jort Custers, Jerome Langedijk, Johannes P. Kwaks, Ted Bakkers, Mark J.G. Zuijdgeest, David Huber, Sietske K. Rosendahl Atyeo, Caroline Fischinger, Stephanie Burke, John S. Feldman, Jared Hauser, Blake M. Caradonna, Timothy M. Bondzie, Esther A. Dagotto, Gabriel Gebre, Makda S. Hoffman, Emily Jacob-Dolan, Catherine Kirilova, Marinela Li, Zhenfeng Lin, Zijin Mahrokhian, Shant H. Maxfield, Lori F. Nampanya, Felix Nityanandam, Ramya Nkolola, Joseph P. Patel, Shivani Ventura, John D. Verrington, Kaylee Wan, Huahua Pessaint, Laurent Van Ry, Alex Blade, Kelvin Strasbaugh, Amanda Cabus, Mehtap Brown, Renita Cook, Anthony Zouantchangadou, Serge Teow, Elyse Andersen, Hanne Lewis, Mark G. Cai, Yongfei Chen, Bing Schmidt, Aaron G. Reeves, R. Keith Baric, Ralph S. Lauffenburger, Douglas A. Alter, Galit Stoffels, Paul Mammen, Mathai Van Hoof, Johan Schuitemaker, Hanneke Barouch, Dan H. Nature Article A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be required to end the coronavirus disease 2019 (COVID-19) pandemic(1–8). For global deployment and pandemic control, a vaccine that requires only a single immunization would be optimal. Here we show the immunogenicity and protective efficacy of a single dose of adenovirus serotype 26 (Ad26) vector-based vaccines expressing the SARS-CoV-2 spike (S) protein in nonhuman primates. 52 rhesus macaques were immunized with Ad26 vectors encoding S variants or sham control and were challenged with SARS-CoV-2 by the intranasal and intratracheal routes(9,10). The optimal Ad26 vaccine induced robust neutralizing antibody responses and provided complete or near-complete protection in bronchoalveolar lavage and nasal swabs following SARS-CoV-2 challenge. Vaccine-elicited neutralizing antibody titers correlated with protective efficacy, suggesting an immune correlate of protection. These data demonstrate robust single-shot vaccine protection against SARS-CoV-2 in nonhuman primates. The optimal Ad26 vector-based vaccine for SARS-CoV-2, termed Ad26.COV2.S, is currently being evaluated in clinical trials. 2020-07-30 2020-10 /pmc/articles/PMC7581548/ /pubmed/32731257 http://dx.doi.org/10.1038/s41586-020-2607-z Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Mercado, Noe B. Zahn, Roland Wegmann, Frank Loos, Carolin Chandrashekar, Abishek Yu, Jingyou Liu, Jinyan Peter, Lauren McMahan, Katherine Tostanoski, Lisa H. He, Xuan Martinez, David R. Rutten, Lucy Bos, Rinke van Manen, Danielle Vellinga, Jort Custers, Jerome Langedijk, Johannes P. Kwaks, Ted Bakkers, Mark J.G. Zuijdgeest, David Huber, Sietske K. Rosendahl Atyeo, Caroline Fischinger, Stephanie Burke, John S. Feldman, Jared Hauser, Blake M. Caradonna, Timothy M. Bondzie, Esther A. Dagotto, Gabriel Gebre, Makda S. Hoffman, Emily Jacob-Dolan, Catherine Kirilova, Marinela Li, Zhenfeng Lin, Zijin Mahrokhian, Shant H. Maxfield, Lori F. Nampanya, Felix Nityanandam, Ramya Nkolola, Joseph P. Patel, Shivani Ventura, John D. Verrington, Kaylee Wan, Huahua Pessaint, Laurent Van Ry, Alex Blade, Kelvin Strasbaugh, Amanda Cabus, Mehtap Brown, Renita Cook, Anthony Zouantchangadou, Serge Teow, Elyse Andersen, Hanne Lewis, Mark G. Cai, Yongfei Chen, Bing Schmidt, Aaron G. Reeves, R. Keith Baric, Ralph S. Lauffenburger, Douglas A. Alter, Galit Stoffels, Paul Mammen, Mathai Van Hoof, Johan Schuitemaker, Hanneke Barouch, Dan H. Single-Shot Ad26 Vaccine Protects Against SARS-CoV-2 in Rhesus Macaques |
| title | Single-Shot Ad26 Vaccine Protects Against SARS-CoV-2 in Rhesus Macaques |
| title_full | Single-Shot Ad26 Vaccine Protects Against SARS-CoV-2 in Rhesus Macaques |
| title_fullStr | Single-Shot Ad26 Vaccine Protects Against SARS-CoV-2 in Rhesus Macaques |
| title_full_unstemmed | Single-Shot Ad26 Vaccine Protects Against SARS-CoV-2 in Rhesus Macaques |
| title_short | Single-Shot Ad26 Vaccine Protects Against SARS-CoV-2 in Rhesus Macaques |
| title_sort | single-shot ad26 vaccine protects against sars-cov-2 in rhesus macaques |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581548/ https://www.ncbi.nlm.nih.gov/pubmed/32731257 http://dx.doi.org/10.1038/s41586-020-2607-z |
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