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Improved Separation of Odor Responses in Granule Cells of the Olfactory Bulb During Odor Discrimination Learning

In the olfactory bulb, olfactory information is translated into ensemble representations by mitral/tufted cells, and these representations change dynamically in a context-dependent manner. In particular, odor representations in mitral/tufted cells display pattern separation during odor discriminatio...

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Autores principales: Wang, Dejuan, Chen, Yang, Chen, Yiling, Li, Xiaowen, Liu, Penglai, Yin, Zhaoyang, Li, Anan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581703/
https://www.ncbi.nlm.nih.gov/pubmed/33192325
http://dx.doi.org/10.3389/fncel.2020.579349
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author Wang, Dejuan
Chen, Yang
Chen, Yiling
Li, Xiaowen
Liu, Penglai
Yin, Zhaoyang
Li, Anan
author_facet Wang, Dejuan
Chen, Yang
Chen, Yiling
Li, Xiaowen
Liu, Penglai
Yin, Zhaoyang
Li, Anan
author_sort Wang, Dejuan
collection PubMed
description In the olfactory bulb, olfactory information is translated into ensemble representations by mitral/tufted cells, and these representations change dynamically in a context-dependent manner. In particular, odor representations in mitral/tufted cells display pattern separation during odor discrimination learning. Although granule cells provide major inhibitory input to mitral/tufted cells and play an important role in pattern separation and olfactory learning, the dynamics of odor responses in granule cells during odor discrimination learning remain largely unknown. Here, we studied odor responses in granule cells of the olfactory bulb using fiber photometry recordings in awake behaving mice. We found that odors evoked reliable, excitatory responses in the granule cell population. Intriguingly, during odor discrimination learning, odor responses in granule cells exhibited improved separation and contained information about odor value. In conclusion, we show that granule cells in the olfactory bulb display learning-related plasticity, suggesting that they may mediate pattern separation in mitral/tufted cells.
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spelling pubmed-75817032020-11-13 Improved Separation of Odor Responses in Granule Cells of the Olfactory Bulb During Odor Discrimination Learning Wang, Dejuan Chen, Yang Chen, Yiling Li, Xiaowen Liu, Penglai Yin, Zhaoyang Li, Anan Front Cell Neurosci Neuroscience In the olfactory bulb, olfactory information is translated into ensemble representations by mitral/tufted cells, and these representations change dynamically in a context-dependent manner. In particular, odor representations in mitral/tufted cells display pattern separation during odor discrimination learning. Although granule cells provide major inhibitory input to mitral/tufted cells and play an important role in pattern separation and olfactory learning, the dynamics of odor responses in granule cells during odor discrimination learning remain largely unknown. Here, we studied odor responses in granule cells of the olfactory bulb using fiber photometry recordings in awake behaving mice. We found that odors evoked reliable, excitatory responses in the granule cell population. Intriguingly, during odor discrimination learning, odor responses in granule cells exhibited improved separation and contained information about odor value. In conclusion, we show that granule cells in the olfactory bulb display learning-related plasticity, suggesting that they may mediate pattern separation in mitral/tufted cells. Frontiers Media S.A. 2020-10-09 /pmc/articles/PMC7581703/ /pubmed/33192325 http://dx.doi.org/10.3389/fncel.2020.579349 Text en Copyright © 2020 Wang, Chen, Chen, Li, Liu, Yin and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wang, Dejuan
Chen, Yang
Chen, Yiling
Li, Xiaowen
Liu, Penglai
Yin, Zhaoyang
Li, Anan
Improved Separation of Odor Responses in Granule Cells of the Olfactory Bulb During Odor Discrimination Learning
title Improved Separation of Odor Responses in Granule Cells of the Olfactory Bulb During Odor Discrimination Learning
title_full Improved Separation of Odor Responses in Granule Cells of the Olfactory Bulb During Odor Discrimination Learning
title_fullStr Improved Separation of Odor Responses in Granule Cells of the Olfactory Bulb During Odor Discrimination Learning
title_full_unstemmed Improved Separation of Odor Responses in Granule Cells of the Olfactory Bulb During Odor Discrimination Learning
title_short Improved Separation of Odor Responses in Granule Cells of the Olfactory Bulb During Odor Discrimination Learning
title_sort improved separation of odor responses in granule cells of the olfactory bulb during odor discrimination learning
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581703/
https://www.ncbi.nlm.nih.gov/pubmed/33192325
http://dx.doi.org/10.3389/fncel.2020.579349
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