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Comparison of Renal Blood Flow Using Maximum Slope-Based Computed Tomography Perfusion and Ultrasound Flow Probe in Healthy Dogs

Computed tomography (CT) perfusion can analyze tissue perfusion and quantitative parameters, including blood flow, blood volume, and transit time. CT perfusion has been used for evaluating split renal function. However, its applicability in veterinary medicine was not validated. This study aimed to...

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Autores principales: Lee, Sang-Kwon, Jang, Youjung, Jung, Jin-Woo, Je, Hyejin, Choi, Jihye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581705/
https://www.ncbi.nlm.nih.gov/pubmed/33195514
http://dx.doi.org/10.3389/fvets.2020.541747
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author Lee, Sang-Kwon
Jang, Youjung
Jung, Jin-Woo
Je, Hyejin
Choi, Jihye
author_facet Lee, Sang-Kwon
Jang, Youjung
Jung, Jin-Woo
Je, Hyejin
Choi, Jihye
author_sort Lee, Sang-Kwon
collection PubMed
description Computed tomography (CT) perfusion can analyze tissue perfusion and quantitative parameters, including blood flow, blood volume, and transit time. CT perfusion has been used for evaluating split renal function. However, its applicability in veterinary medicine was not validated. This study aimed to evaluate the correlation of renal blood flow (RBF) derived by maximum slope-based CT perfusion and an ultrasonic flow probe and assess the effect of the presence of a pre-existing contrast medium on CT perfusion in the kidneys. In five healthy purpose-bred beagles, CT perfusion was performed at the level of the left renal hila after injection of 1 mg/kg iohexol, during measuring RBF with an ultrasonic flow probe placed on the left renal artery. After post-contrast CT scan with injection of 2 mg/kg iohexol, CT perfusion scan was repeated with the same protocol used in the first perfusion study. The CT perfusion derived RBF was analyzed based on the maximum slope and was compared with the true RBF obtained using an ultrasonic flow probe. Results indicated that CT perfusion derived RBF was significantly correlated with true RBF, although CT perfusion derived RBF did not match the absolute value of the true RBF. It was correlated with the true RBF, even in the presence of a pre-existing contrast medium in the kidney. CT perfusion can estimate the change in individual renal perfusion non-invasively, and this method can be used supplementary to the conventional CT protocol in clinic.
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spelling pubmed-75817052020-11-13 Comparison of Renal Blood Flow Using Maximum Slope-Based Computed Tomography Perfusion and Ultrasound Flow Probe in Healthy Dogs Lee, Sang-Kwon Jang, Youjung Jung, Jin-Woo Je, Hyejin Choi, Jihye Front Vet Sci Veterinary Science Computed tomography (CT) perfusion can analyze tissue perfusion and quantitative parameters, including blood flow, blood volume, and transit time. CT perfusion has been used for evaluating split renal function. However, its applicability in veterinary medicine was not validated. This study aimed to evaluate the correlation of renal blood flow (RBF) derived by maximum slope-based CT perfusion and an ultrasonic flow probe and assess the effect of the presence of a pre-existing contrast medium on CT perfusion in the kidneys. In five healthy purpose-bred beagles, CT perfusion was performed at the level of the left renal hila after injection of 1 mg/kg iohexol, during measuring RBF with an ultrasonic flow probe placed on the left renal artery. After post-contrast CT scan with injection of 2 mg/kg iohexol, CT perfusion scan was repeated with the same protocol used in the first perfusion study. The CT perfusion derived RBF was analyzed based on the maximum slope and was compared with the true RBF obtained using an ultrasonic flow probe. Results indicated that CT perfusion derived RBF was significantly correlated with true RBF, although CT perfusion derived RBF did not match the absolute value of the true RBF. It was correlated with the true RBF, even in the presence of a pre-existing contrast medium in the kidney. CT perfusion can estimate the change in individual renal perfusion non-invasively, and this method can be used supplementary to the conventional CT protocol in clinic. Frontiers Media S.A. 2020-10-09 /pmc/articles/PMC7581705/ /pubmed/33195514 http://dx.doi.org/10.3389/fvets.2020.541747 Text en Copyright © 2020 Lee, Jang, Jung, Je and Choi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Lee, Sang-Kwon
Jang, Youjung
Jung, Jin-Woo
Je, Hyejin
Choi, Jihye
Comparison of Renal Blood Flow Using Maximum Slope-Based Computed Tomography Perfusion and Ultrasound Flow Probe in Healthy Dogs
title Comparison of Renal Blood Flow Using Maximum Slope-Based Computed Tomography Perfusion and Ultrasound Flow Probe in Healthy Dogs
title_full Comparison of Renal Blood Flow Using Maximum Slope-Based Computed Tomography Perfusion and Ultrasound Flow Probe in Healthy Dogs
title_fullStr Comparison of Renal Blood Flow Using Maximum Slope-Based Computed Tomography Perfusion and Ultrasound Flow Probe in Healthy Dogs
title_full_unstemmed Comparison of Renal Blood Flow Using Maximum Slope-Based Computed Tomography Perfusion and Ultrasound Flow Probe in Healthy Dogs
title_short Comparison of Renal Blood Flow Using Maximum Slope-Based Computed Tomography Perfusion and Ultrasound Flow Probe in Healthy Dogs
title_sort comparison of renal blood flow using maximum slope-based computed tomography perfusion and ultrasound flow probe in healthy dogs
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581705/
https://www.ncbi.nlm.nih.gov/pubmed/33195514
http://dx.doi.org/10.3389/fvets.2020.541747
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