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The Role of GITR/GITRL Interaction in Autoimmune Diseases

Glucocorticoid-induced TNFR-related protein (GITR) is a member of the TNFR superfamily which is expressed in various cells, including T cells, natural killer cells and some myeloid cells. GITR is activated by its ligand, GITRL, mainly expressed on antigen presenting cells and endothelial cells. It h...

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Detalles Bibliográficos
Autores principales: Tian, Jie, Zhang, Beibei, Rui, Ke, Wang, Shengjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581784/
https://www.ncbi.nlm.nih.gov/pubmed/33163004
http://dx.doi.org/10.3389/fimmu.2020.588682
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author Tian, Jie
Zhang, Beibei
Rui, Ke
Wang, Shengjun
author_facet Tian, Jie
Zhang, Beibei
Rui, Ke
Wang, Shengjun
author_sort Tian, Jie
collection PubMed
description Glucocorticoid-induced TNFR-related protein (GITR) is a member of the TNFR superfamily which is expressed in various cells, including T cells, natural killer cells and some myeloid cells. GITR is activated by its ligand, GITRL, mainly expressed on antigen presenting cells and endothelial cells. It has been acknowledged that the engagement of GITR can modulate both innate and adaptive immune responses. Accumulated evidence suggests GITR/GITRL interaction is involved in the pathogenesis of tumor, inflammation and autoimmune diseases. In this review, we describe the effects of GITR/GITRL activation on effector T cells, regulatory T cells (Tregs) and myeloid cells; summarize its role and the underlying mechanisms in modulating autoimmune diseases.
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spelling pubmed-75817842020-11-05 The Role of GITR/GITRL Interaction in Autoimmune Diseases Tian, Jie Zhang, Beibei Rui, Ke Wang, Shengjun Front Immunol Immunology Glucocorticoid-induced TNFR-related protein (GITR) is a member of the TNFR superfamily which is expressed in various cells, including T cells, natural killer cells and some myeloid cells. GITR is activated by its ligand, GITRL, mainly expressed on antigen presenting cells and endothelial cells. It has been acknowledged that the engagement of GITR can modulate both innate and adaptive immune responses. Accumulated evidence suggests GITR/GITRL interaction is involved in the pathogenesis of tumor, inflammation and autoimmune diseases. In this review, we describe the effects of GITR/GITRL activation on effector T cells, regulatory T cells (Tregs) and myeloid cells; summarize its role and the underlying mechanisms in modulating autoimmune diseases. Frontiers Media S.A. 2020-10-09 /pmc/articles/PMC7581784/ /pubmed/33163004 http://dx.doi.org/10.3389/fimmu.2020.588682 Text en Copyright © 2020 Tian, Zhang, Rui and Wang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Tian, Jie
Zhang, Beibei
Rui, Ke
Wang, Shengjun
The Role of GITR/GITRL Interaction in Autoimmune Diseases
title The Role of GITR/GITRL Interaction in Autoimmune Diseases
title_full The Role of GITR/GITRL Interaction in Autoimmune Diseases
title_fullStr The Role of GITR/GITRL Interaction in Autoimmune Diseases
title_full_unstemmed The Role of GITR/GITRL Interaction in Autoimmune Diseases
title_short The Role of GITR/GITRL Interaction in Autoimmune Diseases
title_sort role of gitr/gitrl interaction in autoimmune diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581784/
https://www.ncbi.nlm.nih.gov/pubmed/33163004
http://dx.doi.org/10.3389/fimmu.2020.588682
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