Novel PGK1 determines SKP2-dependent AR stability and reprograms granular cell glucose metabolism facilitating ovulation dysfunction

BACKGROUND: Disordered folliculogenesis is a core characteristic of polycystic ovary syndrome (PCOS) and androgen receptors (ARs) are closely associated with hyperandrogenism and abnormalities in folliculogenesis in PCOS. However, whether the new AR binding partner phosphoglycerate kinase 1 (PGK1) i...

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Detalles Bibliográficos
Autores principales: Liu, Xia, Sun, Changfa, Zou, Kexin, Li, Cheng, Chen, Xiaojun, Gu, Hangchao, Zhou, Zhiyang, Yang, Zuwei, Tu, Yaoyao, Qin, Ningxin, Zhao, Yiran, Wu, Yimei, Meng, Yicong, Ding, Guolian, Liu, Xinmei, Sheng, Jianzhong, Yu, Chuanjin, Huang, Hefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581881/
https://www.ncbi.nlm.nih.gov/pubmed/33096483
http://dx.doi.org/10.1016/j.ebiom.2020.103058

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