Cargando…

SP6616 as a Kv2.1 inhibitor efficiently ameliorates peripheral neuropathy in diabetic mice

BACKGROUND: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes severely afflicting the patients, while there is yet no effective medication against this disease. As Kv2.1 channel functions potently in regulating neurological disorders, the present work was to investigate the r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Xialin, Chen, Yun, Xu, Xu, Xu, Xiaoju, Lu, Yin, Huang, Xi, Zhou, Jinpei, Hu, Lihong, Wang, Jiaying, Shen, Xu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581884/ https://www.ncbi.nlm.nih.gov/pubmed/33096484 http://dx.doi.org/10.1016/j.ebiom.2020.103061

Ejemplares similares

Antispasmodic Drug Drofenine as an Inhibitor of Kv2.1 Channel Ameliorates Peripheral Neuropathy in Diabetic Mice
por: Xu, Xiaoju, et al.
Publicado: (2020)

SP6616 as a new Kv2.1 channel inhibitor efficiently promotes β-cell survival involving both PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways
por: Zhou, T T, et al.
Publicado: (2016)

Pentameric assembly of the Kv2.1 tetramerization domain
por: Xu, Zhen, et al.
Publicado: (2022)

Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy
por: Kleinecke, Sandra, et al.
Publicado: (2017)

Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels
por: David, Jens-Peter, et al.
Publicado: (2015)

Molsidomine ameliorates diabetic peripheral neuropathy complications in Wistar rats
por: Nayak B, Pranav, et al.
Publicado: (2021)

Regulation of K(+) Conductance by a Hydrogen Bond in Kv2.1, Kv2.2, and Kv1.2 Channels
por: Zhang, Yuchen, et al.
Publicado: (2021)

Calcimimetic restores diabetic peripheral neuropathy by ameliorating apoptosis and improving autophagy
por: Chung, You Chul, et al.
Publicado: (2018)

Activation of axonal Kv7 channels in human peripheral nerve by flupirtine but not placebo - therapeutic potential for peripheral neuropathies: results of a randomised controlled trial
por: Fleckenstein, Johannes, et al.
Publicado: (2013)

Peripheral Neuropathies Due to Systemic Lupus Erythematosus in China
por: Xianbin, Wang, et al.
Publicado: (2015)

Oligomerization and Spatial Distribution of Kvβ1.1 and Kvβ2.1 Regulatory Subunits
por: Roig, Sara R., et al.
Publicado: (2022)

Binding of Hanatoxin to the Voltage Sensor of Kv2.1
por: Chen, Rong, et al.
Publicado: (2012)

Targeted disruption of Kv2.1-VAPA association provides neuroprotection against ischemic stroke in mice by declustering Kv2.1 channels
por: Schulien, Anthony J., et al.
Publicado: (2020)

The Electrically Silent Kv6.4 Subunit Confers Hyperpolarized Gating Charge Movement in Kv2.1/Kv6.4 Heterotetrameric Channels
por: Bocksteins, Elke, et al.
Publicado: (2012)

Sildenafil Ameliorates Long Term Peripheral Neuropathy in Type II Diabetic Mice
por: Wang, Lei, et al.
Publicado: (2015)

Insulin-Ameliorated Peripheral Motor Neuropathy in Spontaneously Diabetic WBN/Kob Rats
por: OZAKI, Kiyokazu, et al.
Publicado: (2013)

Hydroethanolic extract of Lavandula angustifolia ameliorates vincristine-induced peripheral neuropathy in rats
por: Sahranavard, Shamim, et al.
Publicado: (2022)

The Selectivity Filter Is Involved in the U-Type Inactivation Process of Kv2.1 and Kv3.1 Channels
por: Coonen, Laura, et al.
Publicado: (2020)

Dual Delivery of NGF and bFGF Coacervater Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Schwann Cells Apoptosis
por: Li, Rui, et al.
Publicado: (2017)

Effect of tumor necrosis factor inhibitors on rheumatoid arthritis-induced peripheral neuropathy: A cohort study★
por: Wang, Naizhi, et al.
Publicado: (2012)

The risk factors for diabetic peripheral neuropathy: A meta-analysis
por: Liu, Xiuxiu, et al.
Publicado: (2019)

Unlocking the gating mechanism of Kv2.1 using guangxitoxin
por: Navarro, Marco A., et al.
Publicado: (2019)

Inactivation of the Kv2.1 channel through electromechanical coupling
por: Fernández-Mariño, Ana I., et al.
Publicado: (2023)

Antiallergic drug desloratadine as a selective antagonist of 5HT(2A) receptor ameliorates pathology of Alzheimer's disease model mice by improving microglial dysfunction
por: Lu, Jian, et al.
Publicado: (2020)

Beneficial effect of TNF-α inhibition on diabetic peripheral neuropathy
por: Shi, Xiaohong, et al.
Publicado: (2013)

The association of elevated serum lipocalin 2 levels with diabetic peripheral neuropathy in type 2 diabetes
por: Zhang, Xi, et al.
Publicado: (2021)

Oral administration of Cystine and Theanine ameliorates oxaliplatin-induced chronic peripheral neuropathy in rodents
por: Kawashiri, Takehiro, et al.
Publicado: (2020)

Small extracellular vesicles ameliorate peripheral neuropathy and enhance chemotherapy of oxaliplatin on ovarian cancer
por: Zhang, Yi, et al.
Publicado: (2021)

Klaviersonaten, KV 310, KV 333, KV 545
por: Mozart, Wolfgang Amadeus, 1756-1791
Publicado: (1989)

Tang Luo Ning, a Traditional Chinese Compound Prescription, Ameliorates Schwannopathy of Diabetic Peripheral Neuropathy Rats by Regulating Mitochondrial Dynamics In Vivo and In Vitro
por: Zhu, Jiayue, et al.
Publicado: (2021)

Formononetin ameliorates oxaliplatin-induced peripheral neuropathy via the KEAP1-NRF2-GSTP1 axis
por: Fang, Yuan, et al.
Publicado: (2020)

Modulation of Closed−State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4−AP Induced Potentiation
por: Stas, Jeroen I., et al.
Publicado: (2015)

Kv5, Kv6, Kv8, and Kv9 subunits: No simple silent bystanders
por: Bocksteins, Elke
Publicado: (2016)

Corrigendum: Tang Luo Ning, a Traditional Chinese Compound Prescription, Ameliorates Schwannopathy of Diabetic Peripheral Neuropathy Rats by Regulating Mitochondrial Dynamics In Vivo and In Vitro
por: Zhu, Jiayue, et al.
Publicado: (2021)

Regulation of Pro-Apoptotic Phosphorylation of Kv2.1 K(+) Channels
por: He, Kai, et al.
Publicado: (2015)

Polyphenols of marine red macroalga Symphyocladia latiuscula ameliorate diabetic peripheral neuropathy in experimental animals
por: Samaddar, Suman, et al.
Publicado: (2019)

Targeting Oxidative Stress, Autophagy, and Apoptosis by Quercetin to Ameliorate Cisplatin-induced Peripheral Neuropathy in Rats
por: Mahmoud, Heba A., et al.
Publicado: (2023)

The Inhibitory Effects of Ca(2+) Channel Blocker Nifedipine on Rat Kv2.1 Potassium Channels
por: Li, Xian-Tao, et al.
Publicado: (2015)

The Subfamily-Specific Interaction between Kv2.1 and Kv6.4 Subunits Is Determined by Interactions between the N- and C-termini
por: Bocksteins, Elke, et al.
Publicado: (2014)

GAIT UNSTEADINESS AS AN INDICATOR OF COGNITIVE STATUS IN INDIVIDUALS WITH PERIPHERAL NEUROPATHY
por: Kang, Gu Eon, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3e7kid2qsll2i6rdn9g5kqtdpd