Methyl-Coenzyme M Reductase and Its Post-translational Modifications

The methyl-coenzyme M reductase (MCR) is a central enzyme in anaerobic microbial methane metabolism, which consists of methanogenesis and anaerobic oxidation of methane (AOM). MCR catalyzes the final step of methanogenesis and the first step of AOM to achieve the production and oxidation of methane,...

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Detalles Bibliográficos
Autores principales: Chen, Hao, Gan, Qinglei, Fan, Chenguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581889/
https://www.ncbi.nlm.nih.gov/pubmed/33162960
http://dx.doi.org/10.3389/fmicb.2020.578356
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author Chen, Hao
Gan, Qinglei
Fan, Chenguang
author_facet Chen, Hao
Gan, Qinglei
Fan, Chenguang
author_sort Chen, Hao
collection PubMed
description The methyl-coenzyme M reductase (MCR) is a central enzyme in anaerobic microbial methane metabolism, which consists of methanogenesis and anaerobic oxidation of methane (AOM). MCR catalyzes the final step of methanogenesis and the first step of AOM to achieve the production and oxidation of methane, respectively. Besides a unique nickel tetrahydrocorphinoid (coenzyme F430), MCR also features several unusual post-translational modifications (PTMs), which are assumed to play important roles in regulating MCR functions. However, only few studies have been implemented on MCR PTMs. Therefore, to recapitulate current knowledge and prospect future studies, this review summarizes and discusses studies on MCR and its PTMs.
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spelling pubmed-75818892020-11-05 Methyl-Coenzyme M Reductase and Its Post-translational Modifications Chen, Hao Gan, Qinglei Fan, Chenguang Front Microbiol Microbiology The methyl-coenzyme M reductase (MCR) is a central enzyme in anaerobic microbial methane metabolism, which consists of methanogenesis and anaerobic oxidation of methane (AOM). MCR catalyzes the final step of methanogenesis and the first step of AOM to achieve the production and oxidation of methane, respectively. Besides a unique nickel tetrahydrocorphinoid (coenzyme F430), MCR also features several unusual post-translational modifications (PTMs), which are assumed to play important roles in regulating MCR functions. However, only few studies have been implemented on MCR PTMs. Therefore, to recapitulate current knowledge and prospect future studies, this review summarizes and discusses studies on MCR and its PTMs. Frontiers Media S.A. 2020-10-09 /pmc/articles/PMC7581889/ /pubmed/33162960 http://dx.doi.org/10.3389/fmicb.2020.578356 Text en Copyright © 2020 Chen, Gan and Fan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Chen, Hao
Gan, Qinglei
Fan, Chenguang
Methyl-Coenzyme M Reductase and Its Post-translational Modifications
title Methyl-Coenzyme M Reductase and Its Post-translational Modifications
title_full Methyl-Coenzyme M Reductase and Its Post-translational Modifications
title_fullStr Methyl-Coenzyme M Reductase and Its Post-translational Modifications
title_full_unstemmed Methyl-Coenzyme M Reductase and Its Post-translational Modifications
title_short Methyl-Coenzyme M Reductase and Its Post-translational Modifications
title_sort methyl-coenzyme m reductase and its post-translational modifications
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581889/
https://www.ncbi.nlm.nih.gov/pubmed/33162960
http://dx.doi.org/10.3389/fmicb.2020.578356
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AT ganqinglei methylcoenzymemreductaseanditsposttranslationalmodifications
AT fanchenguang methylcoenzymemreductaseanditsposttranslationalmodifications

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