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Incremental prognostic value and underlying biological pathways of radiomics patterns in medulloblastoma

BACKGROUND: To develop a radiomics signature for predicting overall survival (OS)/progression-free survival (PFS) in patients with medulloblastoma (MB), and to investigate the incremental prognostic value and biological pathways of the radiomics patterns. METHODS: A radiomics signature was construct...

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Detalles Bibliográficos
Autores principales: Yan, Jing, Zhang, Shenghai, Li, Kay Ka-Wai, Wang, Weiwei, Li, Ke, Duan, Wenchao, Yuan, Binke, Wang, Li, Liu, Lei, Zhan, Yunbo, Pei, Dongling, Zhao, Haibiao, Sun, Tao, Sun, Chen, Wang, Wenqing, Liu, Zhen, Hong, Xuanke, Wang, Xiangxiang, Guo, Yu, Li, Wencai, Cheng, Jingliang, Liu, Xianzhi, Ng, Ho-Keung, Li, Zhicheng, Zhang, Zhenyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581926/
https://www.ncbi.nlm.nih.gov/pubmed/33096488
http://dx.doi.org/10.1016/j.ebiom.2020.103093
Descripción
Sumario:BACKGROUND: To develop a radiomics signature for predicting overall survival (OS)/progression-free survival (PFS) in patients with medulloblastoma (MB), and to investigate the incremental prognostic value and biological pathways of the radiomics patterns. METHODS: A radiomics signature was constructed based on magnetic resonance imaging (MRI) from a training cohort (n = 83), and evaluated on a testing cohort (n = 83). Key pathways associated with the signature were identified by RNA-seq (GSE151519). Prognostic value of pathway genes was assessed in a public GSE85218 cohort. FINDINGS: The radiomics-clinicomolecular signature predicted OS (C-index 0.762) and PFS (C-index 0.697) better than either the radiomics signature (C-index: OS: 0.649; PFS: 0.593) or the clinicomolecular signature (C-index: OS: 0.725; PFS: 0.691) alone, with a better calibration and classification accuracy (net reclassification improvement: OS: 0.298, P = 0.022; PFS: 0.252, P = 0.026). Nine pathways were significantly correlated with the radiomics signature. Average expression value of pathway genes achieved significant risk stratification in GSE85218 cohort (log-rank P = 0.016). INTERPRETATION: This study demonstrated radiomics signature, which associated with dysregulated pathways, was an independent parameter conferring incremental value over clinicomolecular factors in survival predictions for MB patients. FUNDING: A full list of funding bodies that contributed to this study can be found in the Acknowledgements section.