Oral Neutrophils: Underestimated Players in Oral Cancer

The composition of the oral milieu reflects oral health. Saliva provides an environment for multiple microorganisms, and contains soluble factors and immune cells. Neutrophils, which rapidly react on the changes in the microenvironment, are a major immune cell population in saliva and thus may serve...

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Autores principales: Domnich, Maksim, Riedesel, Jana, Pylaeva, Ekaterina, Kürten, Cornelius H. L., Buer, Jan, Lang, Stephan, Jablonska, Jadwiga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582090/
https://www.ncbi.nlm.nih.gov/pubmed/33162980
http://dx.doi.org/10.3389/fimmu.2020.565683
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author Domnich, Maksim
Riedesel, Jana
Pylaeva, Ekaterina
Kürten, Cornelius H. L.
Buer, Jan
Lang, Stephan
Jablonska, Jadwiga
author_facet Domnich, Maksim
Riedesel, Jana
Pylaeva, Ekaterina
Kürten, Cornelius H. L.
Buer, Jan
Lang, Stephan
Jablonska, Jadwiga
author_sort Domnich, Maksim
collection PubMed
description The composition of the oral milieu reflects oral health. Saliva provides an environment for multiple microorganisms, and contains soluble factors and immune cells. Neutrophils, which rapidly react on the changes in the microenvironment, are a major immune cell population in saliva and thus may serve as a biomarker for oral pathologies. This review focuses on salivary neutrophils in the oral cavity, their phenotype changes in physiological and pathological conditions, as well as on factors regulating oral neutrophil amount, activation and functionality, with special emphasis on oral cancer and its risk factors.
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spelling pubmed-75820902020-11-05 Oral Neutrophils: Underestimated Players in Oral Cancer Domnich, Maksim Riedesel, Jana Pylaeva, Ekaterina Kürten, Cornelius H. L. Buer, Jan Lang, Stephan Jablonska, Jadwiga Front Immunol Immunology The composition of the oral milieu reflects oral health. Saliva provides an environment for multiple microorganisms, and contains soluble factors and immune cells. Neutrophils, which rapidly react on the changes in the microenvironment, are a major immune cell population in saliva and thus may serve as a biomarker for oral pathologies. This review focuses on salivary neutrophils in the oral cavity, their phenotype changes in physiological and pathological conditions, as well as on factors regulating oral neutrophil amount, activation and functionality, with special emphasis on oral cancer and its risk factors. Frontiers Media S.A. 2020-10-09 /pmc/articles/PMC7582090/ /pubmed/33162980 http://dx.doi.org/10.3389/fimmu.2020.565683 Text en Copyright © 2020 Domnich, Riedesel, Pylaeva, Kürten, Buer, Lang and Jablonska. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Domnich, Maksim
Riedesel, Jana
Pylaeva, Ekaterina
Kürten, Cornelius H. L.
Buer, Jan
Lang, Stephan
Jablonska, Jadwiga
Oral Neutrophils: Underestimated Players in Oral Cancer
title Oral Neutrophils: Underestimated Players in Oral Cancer
title_full Oral Neutrophils: Underestimated Players in Oral Cancer
title_fullStr Oral Neutrophils: Underestimated Players in Oral Cancer
title_full_unstemmed Oral Neutrophils: Underestimated Players in Oral Cancer
title_short Oral Neutrophils: Underestimated Players in Oral Cancer
title_sort oral neutrophils: underestimated players in oral cancer
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582090/
https://www.ncbi.nlm.nih.gov/pubmed/33162980
http://dx.doi.org/10.3389/fimmu.2020.565683
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