Development of Hepatocellular Carcinoma in a Patient with Chronic Hepatitis C 21 Years after Achieving a Sustained Virological Response to Interferon Therapy

A 77-year-old man with chronic hepatitis C (CH-C) infection, who achieved a sustained virological response (SVR) to interferon (IFN) therapy, was followed up regularly. Before IFN therapy, he did not have metabolic diseases, and the histological diagnosis of his chronic hepatitis was stage-3 fibrosi...

Descripción completa

Detalles Bibliográficos
Autores principales: Hara, Tasuku, Ohara, Tomoya, Taniguchi, Masashi, Sakai, Toshiaki, Oka, Kohei, Iwai, Naoto, Tsuji, Toshifumi, Okuda, Takashi, Komaki, Toshiyuki, Sakagami, Junichi, Kagawa, Keizo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582091/
https://www.ncbi.nlm.nih.gov/pubmed/33123390
http://dx.doi.org/10.1155/2020/8824974
_version_ 1783599115942232064
author Hara, Tasuku
Ohara, Tomoya
Taniguchi, Masashi
Sakai, Toshiaki
Oka, Kohei
Iwai, Naoto
Tsuji, Toshifumi
Okuda, Takashi
Komaki, Toshiyuki
Sakagami, Junichi
Kagawa, Keizo
author_facet Hara, Tasuku
Ohara, Tomoya
Taniguchi, Masashi
Sakai, Toshiaki
Oka, Kohei
Iwai, Naoto
Tsuji, Toshifumi
Okuda, Takashi
Komaki, Toshiyuki
Sakagami, Junichi
Kagawa, Keizo
author_sort Hara, Tasuku
collection PubMed
description A 77-year-old man with chronic hepatitis C (CH-C) infection, who achieved a sustained virological response (SVR) to interferon (IFN) therapy, was followed up regularly. Before IFN therapy, he did not have metabolic diseases, and the histological diagnosis of his chronic hepatitis was stage-3 fibrosis. After achieving SVR, the fibrosis-4 (FIB-4) index level dropped once but gradually increased. 21 years after SVR, hepatocellular carcinoma (HCC) was diagnosed by dynamic computed tomography. The HCC was 12 mm in diameter. The HCC was treated with radiofrequency ablation. CH-C patients with advanced fibrosis require long-term follow-up, even after achieving SVR.
format Online
Article
Text
id pubmed-7582091
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-75820912020-10-28 Development of Hepatocellular Carcinoma in a Patient with Chronic Hepatitis C 21 Years after Achieving a Sustained Virological Response to Interferon Therapy Hara, Tasuku Ohara, Tomoya Taniguchi, Masashi Sakai, Toshiaki Oka, Kohei Iwai, Naoto Tsuji, Toshifumi Okuda, Takashi Komaki, Toshiyuki Sakagami, Junichi Kagawa, Keizo Case Reports Hepatol Case Report A 77-year-old man with chronic hepatitis C (CH-C) infection, who achieved a sustained virological response (SVR) to interferon (IFN) therapy, was followed up regularly. Before IFN therapy, he did not have metabolic diseases, and the histological diagnosis of his chronic hepatitis was stage-3 fibrosis. After achieving SVR, the fibrosis-4 (FIB-4) index level dropped once but gradually increased. 21 years after SVR, hepatocellular carcinoma (HCC) was diagnosed by dynamic computed tomography. The HCC was 12 mm in diameter. The HCC was treated with radiofrequency ablation. CH-C patients with advanced fibrosis require long-term follow-up, even after achieving SVR. Hindawi 2020-10-14 /pmc/articles/PMC7582091/ /pubmed/33123390 http://dx.doi.org/10.1155/2020/8824974 Text en Copyright © 2020 Tasuku Hara et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Hara, Tasuku
Ohara, Tomoya
Taniguchi, Masashi
Sakai, Toshiaki
Oka, Kohei
Iwai, Naoto
Tsuji, Toshifumi
Okuda, Takashi
Komaki, Toshiyuki
Sakagami, Junichi
Kagawa, Keizo
Development of Hepatocellular Carcinoma in a Patient with Chronic Hepatitis C 21 Years after Achieving a Sustained Virological Response to Interferon Therapy
title Development of Hepatocellular Carcinoma in a Patient with Chronic Hepatitis C 21 Years after Achieving a Sustained Virological Response to Interferon Therapy
title_full Development of Hepatocellular Carcinoma in a Patient with Chronic Hepatitis C 21 Years after Achieving a Sustained Virological Response to Interferon Therapy
title_fullStr Development of Hepatocellular Carcinoma in a Patient with Chronic Hepatitis C 21 Years after Achieving a Sustained Virological Response to Interferon Therapy
title_full_unstemmed Development of Hepatocellular Carcinoma in a Patient with Chronic Hepatitis C 21 Years after Achieving a Sustained Virological Response to Interferon Therapy
title_short Development of Hepatocellular Carcinoma in a Patient with Chronic Hepatitis C 21 Years after Achieving a Sustained Virological Response to Interferon Therapy
title_sort development of hepatocellular carcinoma in a patient with chronic hepatitis c 21 years after achieving a sustained virological response to interferon therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582091/
https://www.ncbi.nlm.nih.gov/pubmed/33123390
http://dx.doi.org/10.1155/2020/8824974
work_keys_str_mv AT haratasuku developmentofhepatocellularcarcinomainapatientwithchronichepatitisc21yearsafterachievingasustainedvirologicalresponsetointerferontherapy
AT oharatomoya developmentofhepatocellularcarcinomainapatientwithchronichepatitisc21yearsafterachievingasustainedvirologicalresponsetointerferontherapy
AT taniguchimasashi developmentofhepatocellularcarcinomainapatientwithchronichepatitisc21yearsafterachievingasustainedvirologicalresponsetointerferontherapy
AT sakaitoshiaki developmentofhepatocellularcarcinomainapatientwithchronichepatitisc21yearsafterachievingasustainedvirologicalresponsetointerferontherapy
AT okakohei developmentofhepatocellularcarcinomainapatientwithchronichepatitisc21yearsafterachievingasustainedvirologicalresponsetointerferontherapy
AT iwainaoto developmentofhepatocellularcarcinomainapatientwithchronichepatitisc21yearsafterachievingasustainedvirologicalresponsetointerferontherapy
AT tsujitoshifumi developmentofhepatocellularcarcinomainapatientwithchronichepatitisc21yearsafterachievingasustainedvirologicalresponsetointerferontherapy
AT okudatakashi developmentofhepatocellularcarcinomainapatientwithchronichepatitisc21yearsafterachievingasustainedvirologicalresponsetointerferontherapy
AT komakitoshiyuki developmentofhepatocellularcarcinomainapatientwithchronichepatitisc21yearsafterachievingasustainedvirologicalresponsetointerferontherapy
AT sakagamijunichi developmentofhepatocellularcarcinomainapatientwithchronichepatitisc21yearsafterachievingasustainedvirologicalresponsetointerferontherapy
AT kagawakeizo developmentofhepatocellularcarcinomainapatientwithchronichepatitisc21yearsafterachievingasustainedvirologicalresponsetointerferontherapy

Ejemplares similares