Fisetin inhibits proliferation of pancreatic adenocarcinoma by inducing DNA damage via RFXAP/KDM4A-dependent histone H3K36 demethylation

Pancreatic adenocarcinoma (PDAC) is an extremely malignant tumor that is associated with low survival rates. Fisetin is a natural flavonoid that shows diverse antitumor effects, including DNA damage, in various cancers. Increasing studies have demonstrated that epigenetic modifications play critical...

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Detalles Bibliográficos
Autores principales: Ding, Guoping, Xu, Xiaodong, Li, Dan, Chen, Yuhao, Wang, Weimin, Ping, Dongnan, Jia, Shengnan, Cao, Liping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582166/
https://www.ncbi.nlm.nih.gov/pubmed/33093461
http://dx.doi.org/10.1038/s41419-020-03019-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582166/
https://www.ncbi.nlm.nih.gov/pubmed/33093461
http://dx.doi.org/10.1038/s41419-020-03019-2

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