Functional validation of a human GLUD2 variant in a murine model of Parkinson’s disease

Parkinson’s disease (PD) is a common neurodegenerative disease characterized by Lewy body formation and progressive dopaminergic neuron death in the substantia nigra (SN). Genetic susceptibility is a strong risk factor for PD. Previously, a rare gain-of-function variant of GLUD2 glutamate dehydrogen...

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Detalles Bibliográficos
Autores principales: Zhang, Wenlong, Gong, Junwei, Ding, Liuyan, Zhang, Zhiling, Pan, Xiaowen, Chen, Xiang, Guo, Wenyuan, Zhang, Xiaokang, Yang, Xinling, Peng, Guoyou, Lin, Yuwan, Gao, Feng, Li, Yuanquan, Zhu, Xiaoqin, Xuan, Aiguo, Wang, Shu, Sun, Xiangdong, Zhang, Yunlong, Xu, Pingyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582183/
https://www.ncbi.nlm.nih.gov/pubmed/33093440
http://dx.doi.org/10.1038/s41419-020-03043-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582183/
https://www.ncbi.nlm.nih.gov/pubmed/33093440
http://dx.doi.org/10.1038/s41419-020-03043-2

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