Targeting N-myristoylation for therapy of B-cell lymphomas

Myristoylation, the N-terminal modification of proteins with the fatty acid myristate, is critical for membrane targeting and cell signaling. Because cancer cells often have increased N-myristoyltransferase (NMT) expression, NMTs were proposed as anti-cancer targets. To systematically investigate th...

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Detalles Bibliográficos
Autores principales: Beauchamp, Erwan, Yap, Megan C., Iyer, Aishwarya, Perinpanayagam, Maneka A., Gamma, Jay M., Vincent, Krista M., Lakshmanan, Manikandan, Raju, Anandhkumar, Tergaonkar, Vinay, Tan, Soo Yong, Lim, Soon Thye, Dong, Wei-Feng, Postovit, Lynne M., Read, Kevin D., Gray, David W., Wyatt, Paul G., Mackey, John R., Berthiaume, Luc G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582192/
https://www.ncbi.nlm.nih.gov/pubmed/33093447
http://dx.doi.org/10.1038/s41467-020-18998-1

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