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Silver Nanoparticles Protect Skin from Ultraviolet B-Induced Damage in Mice
Ultraviolet (UV) radiation from sunlight has various adverse effects; thus, UV blockage is recommended for preventing sunburn. Common sunscreen ingredients, such as nanosized titanium dioxide and zinc oxide, offer effective protection and enhance cosmetic appearance; however, health concerns have be...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582269/ https://www.ncbi.nlm.nih.gov/pubmed/32992921 http://dx.doi.org/10.3390/ijms21197082 |
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author | Ho, Yu-Yi Sun, Der-Shan Chang, Hsin-Hou |
author_facet | Ho, Yu-Yi Sun, Der-Shan Chang, Hsin-Hou |
author_sort | Ho, Yu-Yi |
collection | PubMed |
description | Ultraviolet (UV) radiation from sunlight has various adverse effects; thus, UV blockage is recommended for preventing sunburn. Common sunscreen ingredients, such as nanosized titanium dioxide and zinc oxide, offer effective protection and enhance cosmetic appearance; however, health concerns have been raised regarding their photocatalytic activity, which generates reactive oxygen species under UV illumination. Silver nanoparticles (AgNPs) are known as safe materials for use in a wide spectrum of biomedical applications. In vitro studies have revealed that AgNPs may have a protective effect against UV irradiation, but the effects in animal studies remain unclear. The present study demonstrated that AgNPs effectively protect against UVB-induced skin damage both in cell cultures and mouse models. These results suggested that AgNPs are feasible and safe as sunscreen ingredients for protection against UVB-induced skin damage. |
format | Online Article Text |
id | pubmed-7582269 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75822692020-10-28 Silver Nanoparticles Protect Skin from Ultraviolet B-Induced Damage in Mice Ho, Yu-Yi Sun, Der-Shan Chang, Hsin-Hou Int J Mol Sci Article Ultraviolet (UV) radiation from sunlight has various adverse effects; thus, UV blockage is recommended for preventing sunburn. Common sunscreen ingredients, such as nanosized titanium dioxide and zinc oxide, offer effective protection and enhance cosmetic appearance; however, health concerns have been raised regarding their photocatalytic activity, which generates reactive oxygen species under UV illumination. Silver nanoparticles (AgNPs) are known as safe materials for use in a wide spectrum of biomedical applications. In vitro studies have revealed that AgNPs may have a protective effect against UV irradiation, but the effects in animal studies remain unclear. The present study demonstrated that AgNPs effectively protect against UVB-induced skin damage both in cell cultures and mouse models. These results suggested that AgNPs are feasible and safe as sunscreen ingredients for protection against UVB-induced skin damage. MDPI 2020-09-25 /pmc/articles/PMC7582269/ /pubmed/32992921 http://dx.doi.org/10.3390/ijms21197082 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ho, Yu-Yi Sun, Der-Shan Chang, Hsin-Hou Silver Nanoparticles Protect Skin from Ultraviolet B-Induced Damage in Mice |
title | Silver Nanoparticles Protect Skin from Ultraviolet B-Induced Damage in Mice |
title_full | Silver Nanoparticles Protect Skin from Ultraviolet B-Induced Damage in Mice |
title_fullStr | Silver Nanoparticles Protect Skin from Ultraviolet B-Induced Damage in Mice |
title_full_unstemmed | Silver Nanoparticles Protect Skin from Ultraviolet B-Induced Damage in Mice |
title_short | Silver Nanoparticles Protect Skin from Ultraviolet B-Induced Damage in Mice |
title_sort | silver nanoparticles protect skin from ultraviolet b-induced damage in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582269/ https://www.ncbi.nlm.nih.gov/pubmed/32992921 http://dx.doi.org/10.3390/ijms21197082 |
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