Cargando…

Aluminium Binding to Modified Amyloid-β Peptides: Implications for Alzheimer’s Disease

Aluminium (Al) is clearly neurotoxic and considerable evidence exists that Al may play a role in the aetiology or pathogenesis of Alzheimer’s disease (AD). Nevertheless, the link between AD pathology and Al is still open to debate. Therefore, we investigated here the interaction of aluminium ions wi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mocanu, Cosmin Stefan, Jureschi, Monica, Drochioiu, Gabi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582331/ https://www.ncbi.nlm.nih.gov/pubmed/33022965 http://dx.doi.org/10.3390/molecules25194536

Ejemplares similares

A computational study of metal ions interaction with amyloid-β 1–42 peptide structure in hyperpyrexia: Implications for Alzheimer disease
por: Mocanu, Cosmin Stefan, et al.
Publicado: (2022)

Novel Design of Neuropeptide-Based Drugs with β-Sheet Breaking Potential in Amyloid-Beta Cascade: Molecular and Structural Deciphers
por: Mocanu, Cosmin Stefan, et al.
Publicado: (2022)

Zinc Binding to NAP-Type Neuroprotective Peptides: Nuclear Magnetic Resonance Studies and Molecular Modeling
por: Lupaescu, Ancuta-Veronica, et al.
Publicado: (2021)

Molecular dynamics simulation of aluminium binding to amyloid-β and its effect on peptide structure
por: Turner, Matthew, et al.
Publicado: (2019)

Quantum chemical molecular dynamics and metadynamics simulation of aluminium binding to amyloid-β and related peptides
por: Platts, James A.
Publicado: (2020)

Imaging of aluminium and amyloid β in neurodegenerative disease
por: Exley, Christopher, et al.
Publicado: (2020)

A Peptide That Binds Specifically to the β-Amyloid of Alzheimer's Disease: Selection and Assessment of Anti-β-Amyloid Neurotoxic Effects
por: Wang, Fang, et al.
Publicado: (2011)

β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s disease
por: Sun, Xiaojuan, et al.
Publicado: (2015)

Metabolism of amyloid β peptide and pathogenesis of Alzheimer’s disease
por: SAIDO, Takaomi C.
Publicado: (2013)

Alignment of Alzheimer’s disease amyloid β-peptide and klotho
por: LEHRER, STEVEN, et al.
Publicado: (2020)

Metal Binding of Alzheimer’s Amyloid-β and Its Effect on Peptide Self-Assembly
por: Abelein, Axel
Publicado: (2023)

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide
por: Soscia, Stephanie J., et al.
Publicado: (2010)

The β-amyloid peptide compromises Reelin signaling in Alzheimer’s disease
por: Cuchillo-Ibañez, Inmaculada, et al.
Publicado: (2016)

Additive Toxicity of β-Amyloid by a Novel Bioactive Peptide In Vitro: Possible Implications for Alzheimer’s Disease
por: Garcia-Ratés, Sara, et al.
Publicado: (2013)

Amyloid-β-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Aβ peptide. Implications for the pathogenesis of Alzheimer's disease
por: Dinamarca, Margarita C, et al.
Publicado: (2010)

A Robust and Efficient Production and Purification Procedure of Recombinant Alzheimers Disease Methionine-Modified Amyloid-β Peptides
por: Hoarau, Marie, et al.
Publicado: (2016)

Interactions between Amyloid-β and Hemoglobin: Implications for Amyloid Plaque Formation in Alzheimer's Disease
por: Chuang, Jia-Ying, et al.
Publicado: (2012)

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease
por: Pan, Xiao-dong, et al.
Publicado: (2011)

CSF level of β-amyloid peptide predicts mortality in Alzheimer’s disease
por: Boumenir, Adla, et al.
Publicado: (2019)

Pyroglutamate-Modified Amyloid Beta Peptides: Emerging Targets for Alzheimer´s Disease Immunotherapy
por: Perez-Garmendia, Roxanna, et al.
Publicado: (2013)

Correction: A Robust and Efficient Production and Purification Procedure of Recombinant Alzheimers Disease Methionine-Modified Amyloid-β Peptides
por: Hoarau, Marie, et al.
Publicado: (2018)

Microglia receptors and their implications in the response to amyloid β for Alzheimer’s disease pathogenesis
por: Doens, Deborah, et al.
Publicado: (2014)

Physiological Roles of Monomeric Amyloid-β and Implications for Alzheimer’s Disease Therapeutics
por: Jeong, Hyomin, et al.
Publicado: (2022)

Mercury and Alzheimer’s Disease: Hg(II) Ions Display Specific Binding to the Amyloid-β Peptide and Hinder Its Fibrillization
por: Wallin, Cecilia, et al.
Publicado: (2019)

Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer’s Disease
por: Yoon, Sang-Sun, et al.
Publicado: (2012)

Molecular Structure of Cu(II)-Bound Amyloid-β Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer’s Disease
por: Abelein, Axel, et al.
Publicado: (2022)

Protofibrils of Amyloid-β are Important Targets of a Disease-Modifying Approach for Alzheimer’s Disease
por: Ono, Kenjiro, et al.
Publicado: (2020)

Evidence for impaired amyloid β clearance in Alzheimer's disease
por: Wildsmith, Kristin R, et al.
Publicado: (2013)

In Vivo Preclinical Assessment of β-Amyloid–Affine [(11)C]C-PIB Accumulation in Aluminium-Induced Alzheimer’s Disease-Resembling Hypercholesterinaemic Rat Model
por: Képes, Zita, et al.
Publicado: (2022)

Neuroanatomical spread of amyloid β and tau in Alzheimer’s disease: implications for primary prevention
por: Insel, Philip S, et al.
Publicado: (2020)

Cellular response to β‐amyloid neurotoxicity in Alzheimer's disease and implications in new therapeutics
por: Zhang, Haolin, et al.
Publicado: (2023)

β-Amyloid Degradation and Alzheimer's Disease
por: Wang, Deng-Shun, et al.
Publicado: (2006)

Mitochondria, Amyloid β, and Alzheimer's Disease
por: Readnower, Ryan D., et al.
Publicado: (2011)

The Amyloid-β Pathway in Alzheimer’s Disease
por: Hampel, Harald, et al.
Publicado: (2021)

Zinc(II) Binding Site to the Amyloid-β Peptide: Insights from Spectroscopic Studies with a Wide Series of Modified Peptides
por: Alies, Bruno, et al.
Publicado: (2016)

Calcium Ions Promote Formation of Amyloid β-Peptide (1–40) Oligomers Causally Implicated in Neuronal Toxicity of Alzheimer's Disease
por: Itkin, Anna, et al.
Publicado: (2011)

Common molecular mechanism of amyloid pore formation by Alzheimer’s β-amyloid peptide and α-synuclein
por: Di Scala, Coralie, et al.
Publicado: (2016)

Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
por: Yu, W. Haung, et al.
Publicado: (2005)

A facile method for expression and purification of the Alzheimer’s disease-associated amyloid β-peptide
por: Walsh, Dominic M, et al.
Publicado: (2009)

The Physiological Roles of Amyloid-β Peptide Hint at New Ways to Treat Alzheimer's Disease
por: Brothers, Holly M., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_pjsde4bvqdiij7kg0407ev8r36