Cargando…

Cardioprotective Effect of Novel Matrix Metalloproteinase Inhibitors

Background: We recently developed novel matrix metalloproteinase-2 (MMP-2) inhibitor small molecules for cardioprotection against ischemia/reperfusion injury and validated their efficacy in ischemia/reperfusion injury in cardiac myocytes. The aim of the present study was to test our lead compounds f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gömöri, Kamilla, Szabados, Tamara, Kenyeres, Éva, Pipis, Judit, Földesi, Imre, Siska, Andrea, Dormán, György, Ferdinandy, Péter, Görbe, Anikó, Bencsik, Péter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582346/ https://www.ncbi.nlm.nih.gov/pubmed/32977437 http://dx.doi.org/10.3390/ijms21196990

Ejemplares similares

Myocardial ischaemia reperfusion injury and cardioprotection in the presence of sensory neuropathy: Therapeutic options
por: Bencsik, Péter, et al.
Publicado: (2020)

Development of Matrix Metalloproteinase-2 Inhibitors for Cardioprotection
por: Bencsik, Péter, et al.
Publicado: (2018)

Capsaicin-Sensitive Sensory Nerves and the TRPV1 Ion Channel in Cardiac Physiology and Pathologies
por: Szabados, Tamara, et al.
Publicado: (2020)

Matrix Metalloproteinases Repress Hypertrophic Growth in Cardiac Myocytes
por: Euler, Gerhild, et al.
Publicado: (2021)

Altered Cellular Protein Quality Control System Modulates Cardiomyocyte Function in Volume Overload-Induced Hypertrophy
por: Gömöri, Kamilla, et al.
Publicado: (2022)

Subantimicrobial Dose Doxycycline Worsens Chronic Arthritis-Induced Bone Microarchitectural Alterations in a Mouse Model: Role of Matrix Metalloproteinases?
por: Horváth, Ádám, et al.
Publicado: (2019)

Ca2+/calmodulin‐dependent protein kinase II and protein kinase G oxidation contributes to impaired sarcomeric proteins in hypertrophy model
por: Gömöri, Kamilla, et al.
Publicado: (2022)

Sex Difference in Cardioprotection against Acute Myocardial Infarction in MAO-B Knockout Mice In Vivo
por: Heger, Jacqueline, et al.
Publicado: (2023)

Decorin Protects Cardiac Myocytes against Simulated Ischemia/Reperfusion Injury
por: Gáspár, Renáta, et al.
Publicado: (2020)

Lack of Contribution of p66shc and Its Mitochondrial Translocation to Ischemia-Reperfusion Injury and Cardioprotection by Ischemic Preconditioning
por: Boengler, Kerstin, et al.
Publicado: (2017)

Adverse Effects on β‐Adrenergic Receptor Coupling: Ischemic Postconditioning Failed to Preserve Long‐Term Cardiac Function
por: Schreckenberg, Rolf, et al.
Publicado: (2017)

Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Deletion but Not Inhibition of Extracellular PCSK9 Reduces Infarct Sizes Ex Vivo but Not In Vivo
por: Schreckenberg, Rolf, et al.
Publicado: (2022)

A Comorbidity Model of Myocardial Ischemia/Reperfusion Injury and Hypercholesterolemia in Rat Cardiac Myocyte Cultures
por: Makkos, András, et al.
Publicado: (2020)

Cardioprotective efficacy of limb remote ischaemic preconditioning in rats: discrepancy between a meta-analysis and a three-centre in vivo study
por: Sayour, Nabil V, et al.
Publicado: (2023)

Cardioprotective Effects of Voluntary Exercise in a Rat Model: Role of Matrix Metalloproteinase-2
por: Pósa, Anikó, et al.
Publicado: (2015)

l-Alpha-glycerylphosphorylcholine can be cytoprotective or cytotoxic in neonatal rat cardiac myocytes: a double-edged sword phenomenon
por: Tuboly, Eszter, et al.
Publicado: (2019)

Somatostatin and Its Receptors in Myocardial Ischemia/Reperfusion Injury and Cardioprotection
por: Vörös, Imre, et al.
Publicado: (2021)

Effect of a multivitamin preparation supplemented with phytosterol on serum lipids and infarct size in rats fed with normal and high cholesterol diet
por: Csont, Tamás, et al.
Publicado: (2013)

Effects of Bempedoic Acid in Acute Myocardial Infarction in Rats: No Cardioprotection and No Hidden Cardiotoxicity
por: Gergely, Tamás G., et al.
Publicado: (2023)

Definition of hidden drug cardiotoxicity: paradigm change in cardiac safety testing and its clinical implications
por: Ferdinandy, Péter, et al.
Publicado: (2019)

Ischaemic post‐conditioning in rats: Responder and non‐responder differ in transcriptome of mitochondrial proteins
por: Schreckenberg, Rolf, et al.
Publicado: (2020)

Characterization of the CDAA Diet-Induced Non-alcoholic Steatohepatitis Model: Sex-Specific Differences in Inflammation, Fibrosis, and Cholesterol Metabolism in Middle-Aged Mice
por: Kucsera, Dániel, et al.
Publicado: (2021)

Cardiac miRNA Expression and their mRNA Targets in a Rat Model of Prediabetes
por: Sághy, Éva, et al.
Publicado: (2020)

Chronic kidney disease induces left ventricular overexpression of the pro-hypertrophic microRNA-212
por: Sárközy, Márta, et al.
Publicado: (2019)

Calcium Ionophore-Induced Extracellular Vesicles Mediate Cytoprotection against Simulated Ischemia/Reperfusion Injury in Cardiomyocyte-Derived Cell Lines by Inducing Heme Oxygenase 1
por: Pečan, Peter, et al.
Publicado: (2020)

Saxagliptin Cardiotoxicity in Chronic Heart Failure: The Role of DPP4 in the Regulation of Neuropeptide Tone
por: Vörös, Imre, et al.
Publicado: (2022)

Sensory Neuropathy Affects Cardiac miRNA Expression Network Targeting IGF-1, SLC2a-12, EIF-4e, and ULK-2 mRNAs
por: Bencsik, Péter, et al.
Publicado: (2019)

Matrix Metalloproteinase-2 Inhibition in Acute Ischemia-Reperfusion Heart Injury—Cardioprotective Properties of Carvedilol
por: Skrzypiec-Spring, Monika, et al.
Publicado: (2021)

Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in the hair cycle
por: HOU, CHUN, et al.
Publicado: (2016)

IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action
por: Lecour, Sandrine, et al.
Publicado: (2021)

Co‐expression of glycosylated aquaporin‐1 and transcription factor NFAT5 contributes to aortic stiffness in diabetic and atherosclerosis‐prone mice
por: Madonna, Rosalinda, et al.
Publicado: (2020)

Average Consensus over Mobile Wireless Sensor Networks: Weight Matrix Guaranteeing Convergence without Reconfiguration of Edge Weights
por: Kenyeres, Martin, et al.
Publicado: (2020)

Isolated hypercholesterolemia leads to steatosis in the liver without affecting the pancreas
por: Csonka, Csaba, et al.
Publicado: (2017)

Anti-diabetic effect of a preparation of vitamins, minerals and trace elements in diabetic rats: a gender difference
por: Sárközy, Márta, et al.
Publicado: (2014)

Acute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning
por: Baranyai, Tamás, et al.
Publicado: (2015)

The Effects of Alcohol Intoxication and Withdrawal on Hypothalamic Neurohormones and Extrahypothalamic Neurotransmitters
por: Simon, Balázs, et al.
Publicado: (2023)

Telomerase/myocardin expressing mesenchymal cells induce survival and cardiovascular markers in cardiac stromal cells undergoing ischaemia/reperfusion
por: Madonna, Rosalinda, et al.
Publicado: (2021)

Molecular Network Approach Reveals Rictor as a Central Target of Cardiac ProtectomiRs
por: Makkos, András, et al.
Publicado: (2021)

PCSK9 in Myocardial Infarction and Cardioprotection: Importance of Lipid Metabolism and Inflammation
por: Andreadou, Ioanna, et al.
Publicado: (2020)

Circulating Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Cardiac Amyloidosis
por: Tanaka, Komei, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_697mtl3p0ph86frutdkrqpk6ij