Mechanisms of Arrhythmias in the Brugada Syndrome

Arrhythmias in Brugada syndrome patients originate in the right ventricular outflow tract (RVOT). Over the past few decades, the characterization of the unique anatomy and electrophysiology of the RVOT has revealed the arrhythmogenic nature of this region. However, the mechanisms that drive arrhythm...

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Detalles Bibliográficos
Autores principales: Blok, Michiel, Boukens, Bastiaan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582368/
https://www.ncbi.nlm.nih.gov/pubmed/32992720
http://dx.doi.org/10.3390/ijms21197051
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author Blok, Michiel
Boukens, Bastiaan J.
author_facet Blok, Michiel
Boukens, Bastiaan J.
author_sort Blok, Michiel
collection PubMed
description Arrhythmias in Brugada syndrome patients originate in the right ventricular outflow tract (RVOT). Over the past few decades, the characterization of the unique anatomy and electrophysiology of the RVOT has revealed the arrhythmogenic nature of this region. However, the mechanisms that drive arrhythmias in Brugada syndrome patients remain debated as well as the exact site of their occurrence in the RVOT. Identifying the site of origin and mechanism of Brugada syndrome would greatly benefit the development of mechanism-driven treatment strategies.
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spelling pubmed-75823682020-10-28 Mechanisms of Arrhythmias in the Brugada Syndrome Blok, Michiel Boukens, Bastiaan J. Int J Mol Sci Review Arrhythmias in Brugada syndrome patients originate in the right ventricular outflow tract (RVOT). Over the past few decades, the characterization of the unique anatomy and electrophysiology of the RVOT has revealed the arrhythmogenic nature of this region. However, the mechanisms that drive arrhythmias in Brugada syndrome patients remain debated as well as the exact site of their occurrence in the RVOT. Identifying the site of origin and mechanism of Brugada syndrome would greatly benefit the development of mechanism-driven treatment strategies. MDPI 2020-09-25 /pmc/articles/PMC7582368/ /pubmed/32992720 http://dx.doi.org/10.3390/ijms21197051 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Blok, Michiel
Boukens, Bastiaan J.
Mechanisms of Arrhythmias in the Brugada Syndrome
title Mechanisms of Arrhythmias in the Brugada Syndrome
title_full Mechanisms of Arrhythmias in the Brugada Syndrome
title_fullStr Mechanisms of Arrhythmias in the Brugada Syndrome
title_full_unstemmed Mechanisms of Arrhythmias in the Brugada Syndrome
title_short Mechanisms of Arrhythmias in the Brugada Syndrome
title_sort mechanisms of arrhythmias in the brugada syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582368/
https://www.ncbi.nlm.nih.gov/pubmed/32992720
http://dx.doi.org/10.3390/ijms21197051
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